Urinary 6-sulphatoxymelatonin levels and risk of breast cancer in premenopausal women: The ORDET cohort

Eva S. Schernhammer, Franco Berrino, Vittorio Krogh, Giorgio Secreto, Andrea Micheli, Elisabetta Venturelli, Sara Grioni, Christopher T. Sempos, Adalberto Cavalleri, Holger J. Schünemann, Sabrina Strano, Paola Muti

Research output: Contribution to journalArticle

Abstract

Background: Lower urinary melatonin levels are associated with a higher risk of breast cancer in postmenopausal women. Literature for premenopausal women is scant and inconsistent. Methods: In a prospective case-control study, we measured the concentration of 6-sulphatoxymelatonin (aMT6s) in the 12-hour overnight urine of 180 premenopausal women with incident breast cancer and 683 matched controls. Results: In logistic regression models, the multivariate odds ratio (OR) of invasive breast cancer for women in the highest quartile of total overnight aMT6s output compared with the lowest was 1.43 [95% confidence interval (CI), 0.83-2.45; Ptrend = 0.03]. Among current nonsmokers, no association was existent (OR, 1.00; 95% CI, 0.52-1.94; Ptrend = 0.29). We observed an OR of 0.68 between overnight urinary aMT6s level and breast cancer risk in women with invasive breast cancer diagnosed >2 years after urine collection and a significant inverse association in women with a breast cancer diagnosis >8 years after urine collection (OR, 0.17; 95% CI, 0.04-0.71; Ptrend = 0.01). There were no important variations in ORs by tumor stage or hormone receptor status of breast tumors. Conclusion: Overall, we observed a positive association between aMT6s and risk of breast cancer. However, there was some evidence to suggest that this might be driven by the influence of subclinical disease on melatonin levels, with a possible inverse association among women diagnosed further from recruitment. Thus, the influence of lag time on the association between melatonin and breast cancer risk needs to be evaluated in further studies.

Original languageEnglish
Pages (from-to)729-737
Number of pages9
JournalCancer Epidemiology Biomarkers and Prevention
Volume19
Issue number3
DOIs
Publication statusPublished - Mar 2010

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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    Schernhammer, E. S., Berrino, F., Krogh, V., Secreto, G., Micheli, A., Venturelli, E., Grioni, S., Sempos, C. T., Cavalleri, A., Schünemann, H. J., Strano, S., & Muti, P. (2010). Urinary 6-sulphatoxymelatonin levels and risk of breast cancer in premenopausal women: The ORDET cohort. Cancer Epidemiology Biomarkers and Prevention, 19(3), 729-737. https://doi.org/10.1158/1055-9965.EPI-09-1229