Urinary carcinogenic 4-6 ring polycyclic aromatic hydrocarbons in coke oven workers and in subjects belonging to the general population: Role of occupational and environmental exposure

Laura Campo, Silvia Fustinoni, Dario Consonni, Sofia Pavanello, Lucyna Kapka, Ewa Siwinska, Danuta Mielzyňska, PierAlberto Bertazzi

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: A new solid phase microextraction-gas chromatography-mass spectrometry method (SPME-GC-MS) to detect urinary unmetabolized 3-, 6-ring polycyclic aromatic hydrocarbons (PAHs) was applied to coke oven workers and general population subjects with the aim to assess exposure to carcinogenic PAHs, to evaluate the role of occupational and environmental variables on PAHs levels, and to compare present results with those previously obtained with a less sensitive method. Methods: A total of 104 coke oven workers (CW) from Poland [recruited in 2000 (CW-2000; n= 55) and 2006 (CW-2006; n= 49)], and 45 control subjects from the same area, provided urine spot samples for measurement of 10 PAHs (from phenanthrene to benzo[g,h,i]perylene). The comparison between the two methods was performed only on CW-2000 subjects. Information regarding personal characteristics and job variables was collected by a questionnaire. Results: The new method enables the quantification of 5-, 6-ring PAHs; precision and accuracy were in the 7.3-20.8% and 89.4-110% range, respectively; in CW-2000 samples results obtained with the new and the old method were highly correlated (Lin's concordance correlation coefficients: from 0.790 to 0.965); the mean difference between measured PAHS increased with the molecular weight of the analytes (from +5 to +27%). Urinary PAHs were above or equal to the quantification limit, depending on the compound, in 67-100% (min-max), 26-100% and 6-100% of samples from CW-2000, CW-2006 and controls, respectively. Chrysene and benz[a]anthracene were the most abundant carcinogenic PAHs with median levels of 43.4, 13.4, and 2.3. ng/L and 45.9, 14.9, and 0.7. ng/L in CW-2000, CW-2006, and controls, respectively, while benzo[a]pyrene levels were 6.5, 0.7 and

Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalInternational Journal of Hygiene and Environmental Health
Volume217
Issue number2-3
DOIs
Publication statusPublished - Mar 2014

Keywords

  • Biomonitoring
  • Coke oven workers
  • Polycyclic aromatic hydrocarbons
  • SPME-GC/MS

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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