Urinary Concentration, Environmental Concentration, and Respiratory Uptake of Some Solvents: Effect of the Work Load

The physical demands of the workplace differ depending on specific jobs. This implies that workers exposed to the same environmental level of an airborne contaminant can absorb different amounts of it depending on their pulmonary ventilation. Starting from the relationship between the uptake (U) and the urinary concentration of six solvents (C_u) (acetone, styrene, toluene, x ylenes, methylchloroform, tetrachloro-ethylene) and from the equation expressing their lung uptake (U = K • V • C1 • R • T) the expected values of a biological index after a given time of exposure can be derived. Such values are a function not only of the environmental level of exposure (C1) but also of the pulmonary ventilation (V - dependent solvent) and of the retention index (R) (V - R dependent solvent).