Urinary elimination of acetone in experimental and occupational exposure

G. Pezzagno, M. Imbriani, S. Ghittori, E. Capodaglio, J. Huang

Research output: Contribution to journalArticle

Abstract

Fifteen volunteers were exposed to an acetone vapor concentration of 964-8,610 μmol/m3 (56-500 mg/m3) for 2-4 h in an exposure chamber. Ten subjects were at rest during the exposure, and five were exposed at alternate rest and light physical exercise. Subsequently 104 workers occupationally exposed to acetone were studied. The relative uptake averaged about 53%, and the ratio of the alveolar concentration to the environmental concentration averaged about 0.28. Both for the experimentally exposed subjects and the occupationally exposed workers the urinary acetone concentration showed a linear relationship to the corresponding environmental time-weighted average concentration. A linear equation also existed between urinary concentrations and the amounts of acetone absorbed. The findings enable a consideration of the urinary concentration of the unaltered acetone as an appropriate exposure indicator and the proposal of a 'biological equivalent threshold' to be used in the field of biological monitoring.

Original languageEnglish
Pages (from-to)603-608
Number of pages6
JournalScandinavian Journal of Work, Environment and Health
Volume12
Issue number6
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Geography, Planning and Development
  • Health, Toxicology and Mutagenesis

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