Urinary elimination of styrene in experimental and occupational exposure

G. Pezzagno, S. Ghittori, M. Imbriani, E. Capodaglio

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Twenty human volunteers were exposed to styrene vapor at 273-1,654 μmol/m3 (28.4-172.3 mg/m3) for a period of 1 to 3 h at rest (15 cases) and during light physical exercise (5 cases). Subsequently 51 workers occupationally exposed to styrene were studied during a workweek (median value 1,138 μmol/m3, geometric standard deviation 2.23). As expected, the relative uptake averaged about 65%, and the ratio of the alveolar concentration to the time-weighted average of the environmental concentration averaged about 0.15. Both in the experimentally exposed subjects and in the occupationally exposed workers the urinary styrene concentration showed a linear relationship to the corresponding environmental time-weighted average concentration. The correlation coefficients of the regression lines ranged between 0.88 (occupationally exposed group) and more than 0.93 (experimentally exposed groups). The regression coefficients were closely linked to the amount of styrene taken up and to the exposure times. The findings show that the urinary styrene concentration can be used as an appropriate biological exposure indicator whose meaning differs from that of other suggested indices. As an example, in occupationally exposed subjects performing moderate work the urinary styrene concentration corresponding to the time-weighted average of the threshold limit value is 815 nmol/l, and the 95% lower confidence limit (biological threshold) is 740 nmol/l.

Original languageEnglish
Pages (from-to)371-379
Number of pages9
JournalScandinavian Journal of Work, Environment and Health
Volume11
Issue number5
Publication statusPublished - 1985

Fingerprint

Styrene
occupational exposure
Occupational Exposure
worker
physical exercise
regression
Threshold Limit Values
Values
Group
confidence
time
Volunteers
Vapors
Exercise
Light
exposure

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Geography, Planning and Development

Cite this

Urinary elimination of styrene in experimental and occupational exposure. / Pezzagno, G.; Ghittori, S.; Imbriani, M.; Capodaglio, E.

In: Scandinavian Journal of Work, Environment and Health, Vol. 11, No. 5, 1985, p. 371-379.

Research output: Contribution to journalArticle

@article{67b381d7a7a943a09eb24767d41bd1c3,
title = "Urinary elimination of styrene in experimental and occupational exposure",
abstract = "Twenty human volunteers were exposed to styrene vapor at 273-1,654 μmol/m3 (28.4-172.3 mg/m3) for a period of 1 to 3 h at rest (15 cases) and during light physical exercise (5 cases). Subsequently 51 workers occupationally exposed to styrene were studied during a workweek (median value 1,138 μmol/m3, geometric standard deviation 2.23). As expected, the relative uptake averaged about 65{\%}, and the ratio of the alveolar concentration to the time-weighted average of the environmental concentration averaged about 0.15. Both in the experimentally exposed subjects and in the occupationally exposed workers the urinary styrene concentration showed a linear relationship to the corresponding environmental time-weighted average concentration. The correlation coefficients of the regression lines ranged between 0.88 (occupationally exposed group) and more than 0.93 (experimentally exposed groups). The regression coefficients were closely linked to the amount of styrene taken up and to the exposure times. The findings show that the urinary styrene concentration can be used as an appropriate biological exposure indicator whose meaning differs from that of other suggested indices. As an example, in occupationally exposed subjects performing moderate work the urinary styrene concentration corresponding to the time-weighted average of the threshold limit value is 815 nmol/l, and the 95{\%} lower confidence limit (biological threshold) is 740 nmol/l.",
author = "G. Pezzagno and S. Ghittori and M. Imbriani and E. Capodaglio",
year = "1985",
language = "English",
volume = "11",
pages = "371--379",
journal = "Scandinavian Journal of Work, Environment and Health",
issn = "0355-3140",
publisher = "Nordic Association of Occupational Safety and Health",
number = "5",

}

TY - JOUR

T1 - Urinary elimination of styrene in experimental and occupational exposure

AU - Pezzagno, G.

AU - Ghittori, S.

AU - Imbriani, M.

AU - Capodaglio, E.

PY - 1985

Y1 - 1985

N2 - Twenty human volunteers were exposed to styrene vapor at 273-1,654 μmol/m3 (28.4-172.3 mg/m3) for a period of 1 to 3 h at rest (15 cases) and during light physical exercise (5 cases). Subsequently 51 workers occupationally exposed to styrene were studied during a workweek (median value 1,138 μmol/m3, geometric standard deviation 2.23). As expected, the relative uptake averaged about 65%, and the ratio of the alveolar concentration to the time-weighted average of the environmental concentration averaged about 0.15. Both in the experimentally exposed subjects and in the occupationally exposed workers the urinary styrene concentration showed a linear relationship to the corresponding environmental time-weighted average concentration. The correlation coefficients of the regression lines ranged between 0.88 (occupationally exposed group) and more than 0.93 (experimentally exposed groups). The regression coefficients were closely linked to the amount of styrene taken up and to the exposure times. The findings show that the urinary styrene concentration can be used as an appropriate biological exposure indicator whose meaning differs from that of other suggested indices. As an example, in occupationally exposed subjects performing moderate work the urinary styrene concentration corresponding to the time-weighted average of the threshold limit value is 815 nmol/l, and the 95% lower confidence limit (biological threshold) is 740 nmol/l.

AB - Twenty human volunteers were exposed to styrene vapor at 273-1,654 μmol/m3 (28.4-172.3 mg/m3) for a period of 1 to 3 h at rest (15 cases) and during light physical exercise (5 cases). Subsequently 51 workers occupationally exposed to styrene were studied during a workweek (median value 1,138 μmol/m3, geometric standard deviation 2.23). As expected, the relative uptake averaged about 65%, and the ratio of the alveolar concentration to the time-weighted average of the environmental concentration averaged about 0.15. Both in the experimentally exposed subjects and in the occupationally exposed workers the urinary styrene concentration showed a linear relationship to the corresponding environmental time-weighted average concentration. The correlation coefficients of the regression lines ranged between 0.88 (occupationally exposed group) and more than 0.93 (experimentally exposed groups). The regression coefficients were closely linked to the amount of styrene taken up and to the exposure times. The findings show that the urinary styrene concentration can be used as an appropriate biological exposure indicator whose meaning differs from that of other suggested indices. As an example, in occupationally exposed subjects performing moderate work the urinary styrene concentration corresponding to the time-weighted average of the threshold limit value is 815 nmol/l, and the 95% lower confidence limit (biological threshold) is 740 nmol/l.

UR - http://www.scopus.com/inward/record.url?scp=0022414805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022414805&partnerID=8YFLogxK

M3 - Article

C2 - 4071003

AN - SCOPUS:0022414805

VL - 11

SP - 371

EP - 379

JO - Scandinavian Journal of Work, Environment and Health

JF - Scandinavian Journal of Work, Environment and Health

SN - 0355-3140

IS - 5

ER -