Urinary excretion and origin of 11-dehydro-2,3-dinorthromboxane B2 in man

C. Chiabrando; L. Rivoltella; E. Alberti; M. Bonollo; R. Djurup; R. Fanelli

doi:10.1016/0090-6980(93)90117-P

Urinary excretion and origin of 11-dehydro-2,3-dinorthromboxane B2 in man

C. Chiabrando, L. Rivoltella, E. Alberti, M. Bonollo, R. Djurup, R. Fanelli

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article

Abstract

The in vivo biosynthesis of thromboxane B2 (TXB2) in man is currently evaluated by measuring urinary excretion of its major urinary metabolites, 11-dehydro-TXB2 and 2,3-dinor-TXB2. 11-Dehydro-2,3-dinor-TXB2, another prominent metabolite of exogenous TXB2 in man, has never been measured in human urine. We measured urinary 11-dehydro-2,3-dinor-TXB2 in parallel with 11-dehydro-TXB2 and 2,3-dinor-TXB2 by immunoaffinity extraction/gas chromatography-mass spectrometry in healthy non-smokers (n=12) and age-matched smokers (n=11). In non-smokers, urinary excretion of 11-dehydro-2,3-dinor-TXB2, 11-dehydro-TXB2 and 2,3-dinor-TXB2 was 29.7±11.1, 53.6±15.0 and 13.5±2.8 ng/h (mean±SD), respectively. In smokers, only urinary excretion of 2,3-dinor-TXB2 was significantly different (19.7±6.7 ng/h, p

Original language	English
Pages (from-to)	401-411
Number of pages	11
Journal	Prostaglandins
Volume	45
Issue number	5
DOIs	https://doi.org/10.1016/0090-6980(93)90117-P
Publication status	Published - 1993

ASJC Scopus subject areas

Biochemistry
Endocrinology

Access to Document

10.1016/0090-6980(93)90117-P

Fingerprint Dive into the research topics of 'Urinary excretion and origin of 11-dehydro-2,3-dinorthromboxane B2 in man'. Together they form a unique fingerprint.

Cite this

Chiabrando, C., Rivoltella, L., Alberti, E., Bonollo, M., Djurup, R., & Fanelli, R. (1993). Urinary excretion and origin of 11-dehydro-2,3-dinorthromboxane B2 in man. Prostaglandins, 45(5), 401-411. https://doi.org/10.1016/0090-6980(93)90117-P

@article{2535809bdf844ac88394deee532e22cf,

title = "Urinary excretion and origin of 11-dehydro-2,3-dinorthromboxane B2 in man",

abstract = "The in vivo biosynthesis of thromboxane B2 (TXB2) in man is currently evaluated by measuring urinary excretion of its major urinary metabolites, 11-dehydro-TXB2 and 2,3-dinor-TXB2. 11-Dehydro-2,3-dinor-TXB2, another prominent metabolite of exogenous TXB2 in man, has never been measured in human urine. We measured urinary 11-dehydro-2,3-dinor-TXB2 in parallel with 11-dehydro-TXB2 and 2,3-dinor-TXB2 by immunoaffinity extraction/gas chromatography-mass spectrometry in healthy non-smokers (n=12) and age-matched smokers (n=11). In non-smokers, urinary excretion of 11-dehydro-2,3-dinor-TXB2, 11-dehydro-TXB2 and 2,3-dinor-TXB2 was 29.7±11.1, 53.6±15.0 and 13.5±2.8 ng/h (mean±SD), respectively. In smokers, only urinary excretion of 2,3-dinor-TXB2 was significantly different (19.7±6.7 ng/h, p",

author = "C. Chiabrando and L. Rivoltella and E. Alberti and M. Bonollo and R. Djurup and R. Fanelli",

year = "1993",

doi = "10.1016/0090-6980(93)90117-P",

language = "English",

volume = "45",

pages = "401--411",

journal = "Prostaglandins and Other Lipid Mediators",

issn = "1098-8823",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Urinary excretion and origin of 11-dehydro-2,3-dinorthromboxane B2 in man

AU - Chiabrando, C.

AU - Rivoltella, L.

AU - Alberti, E.

AU - Bonollo, M.

AU - Djurup, R.

AU - Fanelli, R.

PY - 1993

Y1 - 1993

N2 - The in vivo biosynthesis of thromboxane B2 (TXB2) in man is currently evaluated by measuring urinary excretion of its major urinary metabolites, 11-dehydro-TXB2 and 2,3-dinor-TXB2. 11-Dehydro-2,3-dinor-TXB2, another prominent metabolite of exogenous TXB2 in man, has never been measured in human urine. We measured urinary 11-dehydro-2,3-dinor-TXB2 in parallel with 11-dehydro-TXB2 and 2,3-dinor-TXB2 by immunoaffinity extraction/gas chromatography-mass spectrometry in healthy non-smokers (n=12) and age-matched smokers (n=11). In non-smokers, urinary excretion of 11-dehydro-2,3-dinor-TXB2, 11-dehydro-TXB2 and 2,3-dinor-TXB2 was 29.7±11.1, 53.6±15.0 and 13.5±2.8 ng/h (mean±SD), respectively. In smokers, only urinary excretion of 2,3-dinor-TXB2 was significantly different (19.7±6.7 ng/h, p

AB - The in vivo biosynthesis of thromboxane B2 (TXB2) in man is currently evaluated by measuring urinary excretion of its major urinary metabolites, 11-dehydro-TXB2 and 2,3-dinor-TXB2. 11-Dehydro-2,3-dinor-TXB2, another prominent metabolite of exogenous TXB2 in man, has never been measured in human urine. We measured urinary 11-dehydro-2,3-dinor-TXB2 in parallel with 11-dehydro-TXB2 and 2,3-dinor-TXB2 by immunoaffinity extraction/gas chromatography-mass spectrometry in healthy non-smokers (n=12) and age-matched smokers (n=11). In non-smokers, urinary excretion of 11-dehydro-2,3-dinor-TXB2, 11-dehydro-TXB2 and 2,3-dinor-TXB2 was 29.7±11.1, 53.6±15.0 and 13.5±2.8 ng/h (mean±SD), respectively. In smokers, only urinary excretion of 2,3-dinor-TXB2 was significantly different (19.7±6.7 ng/h, p

UR - http://www.scopus.com/inward/record.url?scp=0027193768&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027193768&partnerID=8YFLogxK

U2 - 10.1016/0090-6980(93)90117-P

DO - 10.1016/0090-6980(93)90117-P

M3 - Article

C2 - 8321910

AN - SCOPUS:0027193768

VL - 45

SP - 401

EP - 411

JO - Prostaglandins and Other Lipid Mediators

JF - Prostaglandins and Other Lipid Mediators

SN - 1098-8823

IS - 5

ER -