Urinary excretion and origin of 11-dehydro-2,3-dinorthromboxane B2 in man

C. Chiabrando, L. Rivoltella, E. Alberti, M. Bonollo, R. Djurup, R. Fanelli

Research output: Contribution to journalArticlepeer-review

Abstract

The in vivo biosynthesis of thromboxane B2 (TXB2) in man is currently evaluated by measuring urinary excretion of its major urinary metabolites, 11-dehydro-TXB2 and 2,3-dinor-TXB2. 11-Dehydro-2,3-dinor-TXB2, another prominent metabolite of exogenous TXB2 in man, has never been measured in human urine. We measured urinary 11-dehydro-2,3-dinor-TXB2 in parallel with 11-dehydro-TXB2 and 2,3-dinor-TXB2 by immunoaffinity extraction/gas chromatography-mass spectrometry in healthy non-smokers (n=12) and age-matched smokers (n=11). In non-smokers, urinary excretion of 11-dehydro-2,3-dinor-TXB2, 11-dehydro-TXB2 and 2,3-dinor-TXB2 was 29.7±11.1, 53.6±15.0 and 13.5±2.8 ng/h (mean±SD), respectively. In smokers, only urinary excretion of 2,3-dinor-TXB2 was significantly different (19.7±6.7 ng/h, p

Original languageEnglish
Pages (from-to)401-411
Number of pages11
JournalProstaglandins
Volume45
Issue number5
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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