Abstract
The in vivo biosynthesis of thromboxane B2 (TXB2) in man is currently evaluated by measuring urinary excretion of its major urinary metabolites, 11-dehydro-TXB2 and 2,3-dinor-TXB2. 11-Dehydro-2,3-dinor-TXB2, another prominent metabolite of exogenous TXB2 in man, has never been measured in human urine. We measured urinary 11-dehydro-2,3-dinor-TXB2 in parallel with 11-dehydro-TXB2 and 2,3-dinor-TXB2 by immunoaffinity extraction/gas chromatography-mass spectrometry in healthy non-smokers (n=12) and age-matched smokers (n=11). In non-smokers, urinary excretion of 11-dehydro-2,3-dinor-TXB2, 11-dehydro-TXB2 and 2,3-dinor-TXB2 was 29.7±11.1, 53.6±15.0 and 13.5±2.8 ng/h (mean±SD), respectively. In smokers, only urinary excretion of 2,3-dinor-TXB2 was significantly different (19.7±6.7 ng/h, p
| Original language | English |
|---|---|
| Pages (from-to) | 401-411 |
| Number of pages | 11 |
| Journal | Prostaglandins |
| Volume | 45 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1993 |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology
Cite this
Urinary excretion and origin of 11-dehydro-2,3-dinorthromboxane B2 in man. / Chiabrando, C.; Rivoltella, L.; Alberti, E.; Bonollo, M.; Djurup, R.; Fanelli, R.
In: Prostaglandins, Vol. 45, No. 5, 1993, p. 401-411.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Urinary excretion and origin of 11-dehydro-2,3-dinorthromboxane B2 in man
AU - Chiabrando, C.
AU - Rivoltella, L.
AU - Alberti, E.
AU - Bonollo, M.
AU - Djurup, R.
AU - Fanelli, R.
PY - 1993
Y1 - 1993
N2 - The in vivo biosynthesis of thromboxane B2 (TXB2) in man is currently evaluated by measuring urinary excretion of its major urinary metabolites, 11-dehydro-TXB2 and 2,3-dinor-TXB2. 11-Dehydro-2,3-dinor-TXB2, another prominent metabolite of exogenous TXB2 in man, has never been measured in human urine. We measured urinary 11-dehydro-2,3-dinor-TXB2 in parallel with 11-dehydro-TXB2 and 2,3-dinor-TXB2 by immunoaffinity extraction/gas chromatography-mass spectrometry in healthy non-smokers (n=12) and age-matched smokers (n=11). In non-smokers, urinary excretion of 11-dehydro-2,3-dinor-TXB2, 11-dehydro-TXB2 and 2,3-dinor-TXB2 was 29.7±11.1, 53.6±15.0 and 13.5±2.8 ng/h (mean±SD), respectively. In smokers, only urinary excretion of 2,3-dinor-TXB2 was significantly different (19.7±6.7 ng/h, p
AB - The in vivo biosynthesis of thromboxane B2 (TXB2) in man is currently evaluated by measuring urinary excretion of its major urinary metabolites, 11-dehydro-TXB2 and 2,3-dinor-TXB2. 11-Dehydro-2,3-dinor-TXB2, another prominent metabolite of exogenous TXB2 in man, has never been measured in human urine. We measured urinary 11-dehydro-2,3-dinor-TXB2 in parallel with 11-dehydro-TXB2 and 2,3-dinor-TXB2 by immunoaffinity extraction/gas chromatography-mass spectrometry in healthy non-smokers (n=12) and age-matched smokers (n=11). In non-smokers, urinary excretion of 11-dehydro-2,3-dinor-TXB2, 11-dehydro-TXB2 and 2,3-dinor-TXB2 was 29.7±11.1, 53.6±15.0 and 13.5±2.8 ng/h (mean±SD), respectively. In smokers, only urinary excretion of 2,3-dinor-TXB2 was significantly different (19.7±6.7 ng/h, p
UR - http://www.scopus.com/inward/record.url?scp=0027193768&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027193768&partnerID=8YFLogxK
U2 - 10.1016/0090-6980(93)90117-P
DO - 10.1016/0090-6980(93)90117-P
M3 - Article
VL - 45
SP - 401
EP - 411
JO - Prostaglandins and Other Lipid Mediators
JF - Prostaglandins and Other Lipid Mediators
SN - 1098-8823
IS - 5
ER -