Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man

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Abstract

Caffeine (C) metabolism has been studied in rat, monkey (Macaca cynomolgus) and man after oral administration of the compound. Eleven metabolites were quantified in urine; particular attention has been drawn to 4-amino [5-formyl methylamino]1,3-dimethyl uracil (ADMU) because of its structural analogies with 5-fluorouracil. The rat has been found to produce a much larger fraction of ADMU (about 30%) in respect to monkey and man (1-2%). The potential toxicological implications of this findings are discussed.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalToxicology Letters
Volume7
Issue number3
DOIs
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Toxicology

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