Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man

R. Latini; M. Bonati; E. Marzi; S. Garatt1ni

doi:10.1016/0378-4274(81)90080-1

Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man

R. Latini, M. Bonati, E. Marzi, S. Garatt1ni

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Caffeine (C) metabolism has been studied in rat, monkey (Macaca cynomolgus) and man after oral administration of the compound. Eleven metabolites were quantified in urine; particular attention has been drawn to 4-amino [5-formyl methylamino]1,3-dimethyl uracil (ADMU) because of its structural analogies with 5-fluorouracil. The rat has been found to produce a much larger fraction of ADMU (about 30%) in respect to monkey and man (1-2%). The potential toxicological implications of this findings are discussed.

Original language	English
Pages (from-to)	267-272
Number of pages	6
Journal	Toxicology Letters
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/0378-4274(81)90080-1
Publication status	Published - 1981

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(81)90080-1

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abstract = "Caffeine (C) metabolism has been studied in rat, monkey (Macaca cynomolgus) and man after oral administration of the compound. Eleven metabolites were quantified in urine; particular attention has been drawn to 4-amino [5-formyl methylamino]1,3-dimethyl uracil (ADMU) because of its structural analogies with 5-fluorouracil. The rat has been found to produce a much larger fraction of ADMU (about 30%) in respect to monkey and man (1-2%). The potential toxicological implications of this findings are discussed.",

author = "R. Latini and M. Bonati and E. Marzi and S. Garatt1ni",

year = "1981",

doi = "10.1016/0378-4274(81)90080-1",

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AU - Latini, R.

AU - Bonati, M.

AU - Marzi, E.

AU - Garatt1ni, S.

PY - 1981

Y1 - 1981

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AB - Caffeine (C) metabolism has been studied in rat, monkey (Macaca cynomolgus) and man after oral administration of the compound. Eleven metabolites were quantified in urine; particular attention has been drawn to 4-amino [5-formyl methylamino]1,3-dimethyl uracil (ADMU) because of its structural analogies with 5-fluorouracil. The rat has been found to produce a much larger fraction of ADMU (about 30%) in respect to monkey and man (1-2%). The potential toxicological implications of this findings are discussed.

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Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man

Abstract

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