Urinary excretion of brush-border antigen and plasma proteins in early stages of diabetic nephropathy

Antonio Mutti, Rossella Alinovi, Gian Marco Ghiggeri, Enrico Bergamaschi, Giovanni Candiano, Alessandro Rasi, Rosanna Gusmano, Innocente Franchini, Alberico Borghetti

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In 109 patients with insulin-dependent diabetes mellitus (IDDM), we measured the urinary excretion of albumin, the low molecular weight proteins (LMWP) retinol-binding protein (RBP) and beta2-microglobulin (β2m), and brush-border antigens (BBA) revealed by monoclonal antibodies. All such markers of kidney damage and/or dysfunction were higher in diabetic patients than in 44 controls. Increased urinary levels of BBA (p = 0.0001) were associated with higher values of albumin (p = 0.0002), RBP (p = 0.0005) and, to a lesser extent, of β2m (p = 0.1), different combinations of values above the reference limits being observed. Some 30 and 40% of patients with and without microalbuminuria, respectively, also exhibited signs of tubulopathy. Although under certain circumstances tubular defects may give rise to small increases in albuminuria, the most likely explanation for our findings is the coexistence of glomerular and tubular damage in some patients with IDDM. Neither the prognostic value nor the pathophysiological meaning of tubular damage and/or dysfunction can be assessed by the present study, owing to its cross-sectional design. Tubular markers thus deserve further studies to clarify whether in diabetic patients they indicate a more severe or diffuse kidney impairment.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalClinica Chimica Acta
Volume188
Issue number2
DOIs
Publication statusPublished - Apr 30 1990

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Retinol-Binding Proteins
Diabetic Nephropathies
Brushes
Medical problems
Microvilli
Blood Proteins
Albumins
Insulin
Antigens
Type 1 Diabetes Mellitus
Molecular weight
Monoclonal Antibodies
Defects
Kidney
Albuminuria
Reference Values
Molecular Weight
Proteins
Protein Binding

Keywords

  • Brush-border antigen
  • Diabetic nephropathy
  • Microalbuminuria
  • Proteinuria
  • Tubular damage

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Urinary excretion of brush-border antigen and plasma proteins in early stages of diabetic nephropathy. / Mutti, Antonio; Alinovi, Rossella; Ghiggeri, Gian Marco; Bergamaschi, Enrico; Candiano, Giovanni; Rasi, Alessandro; Gusmano, Rosanna; Franchini, Innocente; Borghetti, Alberico.

In: Clinica Chimica Acta, Vol. 188, No. 2, 30.04.1990, p. 93-100.

Research output: Contribution to journalArticle

Mutti, A, Alinovi, R, Ghiggeri, GM, Bergamaschi, E, Candiano, G, Rasi, A, Gusmano, R, Franchini, I & Borghetti, A 1990, 'Urinary excretion of brush-border antigen and plasma proteins in early stages of diabetic nephropathy', Clinica Chimica Acta, vol. 188, no. 2, pp. 93-100. https://doi.org/10.1016/0009-8981(90)90153-J
Mutti, Antonio ; Alinovi, Rossella ; Ghiggeri, Gian Marco ; Bergamaschi, Enrico ; Candiano, Giovanni ; Rasi, Alessandro ; Gusmano, Rosanna ; Franchini, Innocente ; Borghetti, Alberico. / Urinary excretion of brush-border antigen and plasma proteins in early stages of diabetic nephropathy. In: Clinica Chimica Acta. 1990 ; Vol. 188, No. 2. pp. 93-100.
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