Urinary excretion of ethylenethiourea in five volunteers on a controlled diet (multicentric study)

C. Aprea, A. Betta, G. Catenacci, A. Colli, A. Lotti, C. Minoia, P. Olivieri, V. Passini, I. Pavan, C. Roggi, R. Ruggeri, G. Sciarra, R. Turci, P. Vannini, V. Vitalone

Research output: Contribution to journalArticlepeer-review


Urinary excretion of ethylenethiourea (ETU) was monitored for 8 days in a group of five male non-smoker volunteers on a diet, the items of which were assayed for ETU and carbon sulphide. Urinary excretion of ETU reflected the consumption of wine, fruit and vegetables. Urinary ETU concentrations ranged from 0.6 to 6.7 μg/g creatinine. ETU concentrations in the food eaten by the volunteers were generally below the detection limit whereas in wine 8.8 μg/l ETU was detected. Evolution of carbon sulphide by food samples ranged from 0.03 to 0.17 mg/kg. Mean (± S.D.) daily intake of ETU in wine was 3.5 ± 0.2% of the acceptable daily intake (ADI): 0.070 ± 0.004 μg/kg body wt. During the 8 days of the study, an average of 48.3% of the ETU ingested in wine was excreted unmodified by the kidneys. Twenty-four-hour urinary excretion of ETU was significantly correlated with daily intake of ETU (r = 0.768) and CS2 evolved by the daily food items (r = 0.414).

Original languageEnglish
Pages (from-to)167-179
Number of pages13
JournalScience of the Total Environment
Issue number2
Publication statusPublished - Sep 6 1997


  • Dietary intake
  • Ethylenebisdithiocarbamates
  • Ethylenethiourea
  • General population

ASJC Scopus subject areas

  • Environmental Chemistry
  • Environmental Science(all)


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