Urinary excretion of platelet-activating factor in haemolytic uraemic syndrome

A. Benigni, P. Boccardo, M. Noris, G. Remuzzi, R. L. Siegler

Research output: Contribution to journalArticle

Abstract

Since some of the features of haemolytic uraemic syndrome (HUS), such as platelet activation and glomerular injury, could be brought about by platelet-activating factor (PAF), we have studied the urinary excretion of PAF in 10 children with HUS and in 10 healthy age-matched controls. Urinary PAF concentrations, measured by radioimmunoassay, were significantly higher in acute-phase H US patients than in controls (mean 2·04 [SD 1·66] vs 0·72 [0·43] ng/mg creatinine, p <0·05) but were similar to those in controls in samples taken after recovery. High PAF concentrations during the acute phase of HUS may reflect platelet activation and glomerular injury; the lower values after recovery suggest that urinary PAF may be a marker of disease activity.

Original languageEnglish
Pages (from-to)835-836
Number of pages2
JournalLancet
Volume339
Issue number8797
DOIs
Publication statusPublished - Apr 4 1992

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ASJC Scopus subject areas

  • Medicine(all)

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