Abstract
The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R2=0,782 (p2=0,862 (p
| Original language | Italian |
|---|---|
| Pages (from-to) | 95-97 |
| Number of pages | 3 |
| Journal | Giornale Italiano di Medicina del Lavoro ed Ergonomia |
| Volume | 25 |
| Issue number | SUPPL. 3 |
| Publication status | Published - Jul 2003 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Rehabilitation
Cite this
L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano : Aspetti metodologici e punti critici. / Barbic, F.; Bagnati, M.; Basile, M.; Zanoli, V.; Carettoni, L.; Cassani, C.; Porta, P.; Fortina, A.; Mantovani, C.; Bellomo, G.
In: Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 25, No. SUPPL. 3, 07.2003, p. 95-97.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano
T2 - Aspetti metodologici e punti critici
AU - Barbic, F.
AU - Bagnati, M.
AU - Basile, M.
AU - Zanoli, V.
AU - Carettoni, L.
AU - Cassani, C.
AU - Porta, P.
AU - Fortina, A.
AU - Mantovani, C.
AU - Bellomo, G.
PY - 2003/7
Y1 - 2003/7
N2 - The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R2=0,782 (p2=0,862 (p
AB - The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R2=0,782 (p2=0,862 (p
KW - Occupational exposure
KW - Sevoflurane
KW - Urinary hexafluoroisopropanol
UR - http://www.scopus.com/inward/record.url?scp=10744221355&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10744221355&partnerID=8YFLogxK
M3 - Articolo
C2 - 14979101
AN - SCOPUS:10744221355
VL - 25
SP - 95
EP - 97
JO - Giornale Italiano di Medicina del Lavoro ed Ergonomia
JF - Giornale Italiano di Medicina del Lavoro ed Ergonomia
SN - 1592-7830
IS - SUPPL. 3
ER -