L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici

Translated title of the contribution: Urinary hexafluoroisopropanol in the evaluation of occupational exposure to sevoflurane: Methodological aspects and critical points

F. Barbic, M. Bagnati, M. Basile, V. Zanoli, L. Carettoni, C. Cassani, P. Porta, A. Fortina, C. Mantovani, G. Bellomo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R2=0,782 (p2=0,862 (p

Original languageItalian
Pages (from-to)95-97
Number of pages3
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume25
Issue numberSUPPL. 3
Publication statusPublished - Jul 2003

Fingerprint

Occupational Exposure
Glucuronides
Urine
Operating Rooms
sevoflurane
hexafluoroisopropanol
Anesthetics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Rehabilitation

Cite this

L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano : Aspetti metodologici e punti critici. / Barbic, F.; Bagnati, M.; Basile, M.; Zanoli, V.; Carettoni, L.; Cassani, C.; Porta, P.; Fortina, A.; Mantovani, C.; Bellomo, G.

In: Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 25, No. SUPPL. 3, 07.2003, p. 95-97.

Research output: Contribution to journalArticle

Barbic, F, Bagnati, M, Basile, M, Zanoli, V, Carettoni, L, Cassani, C, Porta, P, Fortina, A, Mantovani, C & Bellomo, G 2003, 'L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici', Giornale Italiano di Medicina del Lavoro ed Ergonomia, vol. 25, no. SUPPL. 3, pp. 95-97.
Barbic, F. ; Bagnati, M. ; Basile, M. ; Zanoli, V. ; Carettoni, L. ; Cassani, C. ; Porta, P. ; Fortina, A. ; Mantovani, C. ; Bellomo, G. / L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano : Aspetti metodologici e punti critici. In: Giornale Italiano di Medicina del Lavoro ed Ergonomia. 2003 ; Vol. 25, No. SUPPL. 3. pp. 95-97.
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