Abstract
The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R2=0,782 (p2=0,862 (p
Translated title of the contribution | Urinary hexafluoroisopropanol in the evaluation of occupational exposure to sevoflurane: Methodological aspects and critical points |
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Original language | Italian |
Pages (from-to) | 95-97 |
Number of pages | 3 |
Journal | Giornale Italiano di Medicina del Lavoro ed Ergonomia |
Volume | 25 |
Issue number | SUPPL. 3 |
Publication status | Published - Jul 2003 |
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Rehabilitation