L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici

F. Barbic; M. Bagnati; M. Basile; V. Zanoli; L. Carettoni; C. Cassani; P. Porta; A. Fortina; C. Mantovani; G. Bellomo

L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici

Translated title of the contribution: Urinary hexafluoroisopropanol in the evaluation of occupational exposure to sevoflurane: Methodological aspects and critical points

F. Barbic, M. Bagnati, M. Basile, V. Zanoli, L. Carettoni, C. Cassani, P. Porta, A. Fortina, C. Mantovani, G. Bellomo

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R²=0,782 (p2=0,862 (p

Translated title of the contribution	Urinary hexafluoroisopropanol in the evaluation of occupational exposure to sevoflurane: Methodological aspects and critical points
Original language	Italian
Pages (from-to)	95-97
Number of pages	3
Journal	Giornale Italiano di Medicina del Lavoro ed Ergonomia
Volume	25
Issue number	SUPPL. 3
Publication status	Published - Jul 2003

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Rehabilitation

Cite this

@article{eb23f9888b3f4934b4bc8fe258aaed98,

title = "L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici",

abstract = "The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R2=0,782 (p2=0,862 (p",

keywords = "Occupational exposure, Sevoflurane, Urinary hexafluoroisopropanol",

author = "F. Barbic and M. Bagnati and M. Basile and V. Zanoli and L. Carettoni and C. Cassani and P. Porta and A. Fortina and C. Mantovani and G. Bellomo",

year = "2003",

month = jul,

language = "Italian",

volume = "25",

pages = "95--97",

journal = "Giornale Italiano di Medicina del Lavoro ed Ergonomia",

issn = "1592-7830",

publisher = "Tipografia PI-ME Editrice Srl",

number = "SUPPL. 3",

}

TY - JOUR

T1 - L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano

T2 - Aspetti metodologici e punti critici

AU - Barbic, F.

AU - Bagnati, M.

AU - Basile, M.

AU - Zanoli, V.

AU - Carettoni, L.

AU - Cassani, C.

AU - Porta, P.

AU - Fortina, A.

AU - Mantovani, C.

AU - Bellomo, G.

PY - 2003/7

Y1 - 2003/7

N2 - The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R2=0,782 (p2=0,862 (p

AB - The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R2=0,782 (p2=0,862 (p

KW - Occupational exposure

KW - Sevoflurane

KW - Urinary hexafluoroisopropanol

UR - http://www.scopus.com/inward/record.url?scp=10744221355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744221355&partnerID=8YFLogxK

M3 - Articolo

C2 - 14979101

AN - SCOPUS:10744221355

VL - 25

SP - 95

EP - 97

JO - Giornale Italiano di Medicina del Lavoro ed Ergonomia

JF - Giornale Italiano di Medicina del Lavoro ed Ergonomia

SN - 1592-7830

IS - SUPPL. 3

ER -

L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this