L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici

F. Barbic; M. Bagnati; M. Basile; V. Zanoli; L. Carettoni; C. Cassani; P. Porta; A. Fortina; C. Mantovani; G. Bellomo

L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici

Translated title of the contribution: Urinary hexafluoroisopropanol in the evaluation of occupational exposure to sevoflurane: Methodological aspects and critical points

F. Barbic, M. Bagnati, M. Basile, V. Zanoli, L. Carettoni, C. Cassani, P. Porta, A. Fortina, C. Mantovani, G. Bellomo

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R²=0,782 (p2=0,862 (p

Translated title of the contribution	Urinary hexafluoroisopropanol in the evaluation of occupational exposure to sevoflurane: Methodological aspects and critical points
Original language	Italian
Pages (from-to)	95-97
Number of pages	3
Journal	Giornale Italiano di Medicina del Lavoro ed Ergonomia
Volume	25
Issue number	SUPPL. 3
Publication status	Published - Jul 2003

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Rehabilitation

Cite this

L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano : Aspetti metodologici e punti critici. / Barbic, F.; Bagnati, M.; Basile, M.; Zanoli, V.; Carettoni, L.; Cassani, C.; Porta, P.; Fortina, A.; Mantovani, C.; Bellomo, G.

In: Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 25, No. SUPPL. 3, 07.2003, p. 95-97.

Research output: Contribution to journal › Article › peer-review

Barbic, F. ; Bagnati, M. ; Basile, M. ; Zanoli, V. ; Carettoni, L. ; Cassani, C. ; Porta, P. ; Fortina, A. ; Mantovani, C. ; Bellomo, G. / L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano : Aspetti metodologici e punti critici. In: Giornale Italiano di Medicina del Lavoro ed Ergonomia. 2003 ; Vol. 25, No. SUPPL. 3. pp. 95-97.

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L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici

Abstract

ASJC Scopus subject areas

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