L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici

F. Barbic; M. Bagnati; M. Basile; V. Zanoli; L. Carettoni; C. Cassani; P. Porta; A. Fortina; C. Mantovani; G. Bellomo

L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici

Translated title of the contribution: Urinary hexafluoroisopropanol in the evaluation of occupational exposure to sevoflurane: Methodological aspects and critical points

F. Barbic, M. Bagnati, M. Basile, V. Zanoli, L. Carettoni, C. Cassani, P. Porta, A. Fortina, C. Mantovani, G. Bellomo

Istituto Clinico Humanitas

Research output: Contribution to journal › Article

Abstract

The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R²=0,782 (p2=0,862 (p

Translated title of the contribution	Urinary hexafluoroisopropanol in the evaluation of occupational exposure to sevoflurane: Methodological aspects and critical points
Original language	Italian
Pages (from-to)	95-97
Number of pages	3
Journal	Giornale Italiano di Medicina del Lavoro ed Ergonomia
Volume	25
Issue number	SUPPL. 3
Publication status	Published - Jul 2003

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Rehabilitation

Access to Document

Fingerprint Dive into the research topics of 'Urinary hexafluoroisopropanol in the evaluation of occupational exposure to sevoflurane: Methodological aspects and critical points'. Together they form a unique fingerprint.

Cite this

Barbic, F., Bagnati, M., Basile, M., Zanoli, V., Carettoni, L., Cassani, C., Porta, P., Fortina, A., Mantovani, C., & Bellomo, G. (2003). L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici. Giornale Italiano di Medicina del Lavoro ed Ergonomia, 25(SUPPL. 3), 95-97.

L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano : Aspetti metodologici e punti critici. / Barbic, F.; Bagnati, M.; Basile, M.; Zanoli, V.; Carettoni, L.; Cassani, C.; Porta, P.; Fortina, A.; Mantovani, C.; Bellomo, G.

In: Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 25, No. SUPPL. 3, 07.2003, p. 95-97.

Research output: Contribution to journal › Article

Barbic, F. ; Bagnati, M. ; Basile, M. ; Zanoli, V. ; Carettoni, L. ; Cassani, C. ; Porta, P. ; Fortina, A. ; Mantovani, C. ; Bellomo, G. / L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano : Aspetti metodologici e punti critici. In: Giornale Italiano di Medicina del Lavoro ed Ergonomia. 2003 ; Vol. 25, No. SUPPL. 3. pp. 95-97.

@article{eb23f9888b3f4934b4bc8fe258aaed98,

title = "L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici",

abstract = "The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R2=0,782 (p2=0,862 (p",

keywords = "Occupational exposure, Sevoflurane, Urinary hexafluoroisopropanol",

author = "F. Barbic and M. Bagnati and M. Basile and V. Zanoli and L. Carettoni and C. Cassani and P. Porta and A. Fortina and C. Mantovani and G. Bellomo",

year = "2003",

month = jul,

language = "Italian",

volume = "25",

pages = "95--97",

journal = "Giornale Italiano di Medicina del Lavoro ed Ergonomia",

issn = "1592-7830",

publisher = "Tipografia PI-ME Editrice Srl",

number = "SUPPL. 3",

}

TY - JOUR

T1 - L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano

T2 - Aspetti metodologici e punti critici

AU - Barbic, F.

AU - Bagnati, M.

AU - Basile, M.

AU - Zanoli, V.

AU - Carettoni, L.

AU - Cassani, C.

AU - Porta, P.

AU - Fortina, A.

AU - Mantovani, C.

AU - Bellomo, G.

PY - 2003/7

Y1 - 2003/7

N2 - The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R2=0,782 (p2=0,862 (p

AB - The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R2=0,782 (p2=0,862 (p

KW - Occupational exposure

KW - Sevoflurane

KW - Urinary hexafluoroisopropanol

UR - http://www.scopus.com/inward/record.url?scp=10744221355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744221355&partnerID=8YFLogxK

M3 - Articolo

C2 - 14979101

AN - SCOPUS:10744221355

VL - 25

SP - 95

EP - 97

JO - Giornale Italiano di Medicina del Lavoro ed Ergonomia

JF - Giornale Italiano di Medicina del Lavoro ed Ergonomia

SN - 1592-7830

IS - SUPPL. 3

ER -