L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici

Translated title of the contribution: Urinary hexafluoroisopropanol in the evaluation of occupational exposure to sevoflurane: Methodological aspects and critical points

F. Barbic, M. Bagnati, M. Basile, V. Zanoli, L. Carettoni, C. Cassani, P. Porta, A. Fortina, C. Mantovani, G. Bellomo

Research output: Contribution to journalArticle

Abstract

The increasing use of sevoflurane as anaesthetic leads to the need for finding a biological index to evaluate the occupational exposure in surgical activity. Several studies indicate that Hexafluoroisopropanol (HFIP) is a specific sevoflurane metabolite quickly glucuronidated and excreted as HFIP-glucuronide in the urine (HFIPu). Therefore the HFIP removal kinetics in occupational exposure and the correlation between sevoflurane exposure and HFIPu are poorly understood. We studied n° 86 operating room workers of Novara Hospital to evaluate the correlation between the sevoflurane individual exposure (SE) and the HFIPu at the end of the shift expressed in μg/L (A-HFIPu) and in μg/g creat. (C-HFIPu). Therefore, in the same group of subjects we evaluated the HFIPu in the urine sampled at 8.00 a.m. before the work. The correlation coefficient was R2=0,782 (p2=0,862 (p

Translated title of the contributionUrinary hexafluoroisopropanol in the evaluation of occupational exposure to sevoflurane: Methodological aspects and critical points
Original languageItalian
Pages (from-to)95-97
Number of pages3
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume25
Issue numberSUPPL. 3
Publication statusPublished - Jul 2003

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Rehabilitation

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    Barbic, F., Bagnati, M., Basile, M., Zanoli, V., Carettoni, L., Cassani, C., Porta, P., Fortina, A., Mantovani, C., & Bellomo, G. (2003). L'esafluoroisopropanolo urinario nella valutazione dell'esposizione professionale a sevofluorano: Aspetti metodologici e punti critici. Giornale Italiano di Medicina del Lavoro ed Ergonomia, 25(SUPPL. 3), 95-97.