Abstract
Bombesin-related peptides (BRP) are present in the lung and have various biological functions, including modulation of lung maturation. Many recent studies have suggested that BRP have a pathogenic role in airway wall remodeling in chronic obstructive pulmonary disease. The aim of this cross- sectional survey was to evaluate the distribution of urinary BRP excretion as a indirect marker of pulmonary BRP production and to assess the prevalence of smoking, chronic respiratory symptoms, chronic obstructive pulmonary disease, and asthma in a population sample from northern Italy. Associations between urinary BRP excretion and several respiratory and nonrespiratory variables were also evaluated. The only variable tested that was significantly predictive of high urinary levels of BRP was the presence of respiratory symptoms. In contrast to previous studies, smoking per se was not significantly associated with urinary BRP levels.
| Original language | English |
|---|---|
| Pages (from-to) | 258-265 |
| Number of pages | 8 |
| Journal | American Journal of the Medical Sciences |
| Volume | 315 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1998 |
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Keywords
- Asthma
- Bombesin-related peptides
- Chronic bronchitis
- Chronic obstructive pulmonary disease prevalence
- Pulmonary neuroendocrine cells
- Tobacco smoke
ASJC Scopus subject areas
- Medicine(all)
Cite this
Urinary levels of bombesin-related peptides in a population sample from northern Italy : Potential role in the pathogenesis of chronic obstructive pulmonary disease. / Meloni, Federica; Ballabio, Piercarla; Pistorio, Angela; Todarello, Caterina; Montoli, Claudio; Berrayah, Laiachi; Meloni, Cesare; Grassi, Carlo; Aguayo, Samuel M.
In: American Journal of the Medical Sciences, Vol. 315, No. 4, 1998, p. 258-265.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Urinary levels of bombesin-related peptides in a population sample from northern Italy
T2 - Potential role in the pathogenesis of chronic obstructive pulmonary disease
AU - Meloni, Federica
AU - Ballabio, Piercarla
AU - Pistorio, Angela
AU - Todarello, Caterina
AU - Montoli, Claudio
AU - Berrayah, Laiachi
AU - Meloni, Cesare
AU - Grassi, Carlo
AU - Aguayo, Samuel M.
PY - 1998
Y1 - 1998
N2 - Bombesin-related peptides (BRP) are present in the lung and have various biological functions, including modulation of lung maturation. Many recent studies have suggested that BRP have a pathogenic role in airway wall remodeling in chronic obstructive pulmonary disease. The aim of this cross- sectional survey was to evaluate the distribution of urinary BRP excretion as a indirect marker of pulmonary BRP production and to assess the prevalence of smoking, chronic respiratory symptoms, chronic obstructive pulmonary disease, and asthma in a population sample from northern Italy. Associations between urinary BRP excretion and several respiratory and nonrespiratory variables were also evaluated. The only variable tested that was significantly predictive of high urinary levels of BRP was the presence of respiratory symptoms. In contrast to previous studies, smoking per se was not significantly associated with urinary BRP levels.
AB - Bombesin-related peptides (BRP) are present in the lung and have various biological functions, including modulation of lung maturation. Many recent studies have suggested that BRP have a pathogenic role in airway wall remodeling in chronic obstructive pulmonary disease. The aim of this cross- sectional survey was to evaluate the distribution of urinary BRP excretion as a indirect marker of pulmonary BRP production and to assess the prevalence of smoking, chronic respiratory symptoms, chronic obstructive pulmonary disease, and asthma in a population sample from northern Italy. Associations between urinary BRP excretion and several respiratory and nonrespiratory variables were also evaluated. The only variable tested that was significantly predictive of high urinary levels of BRP was the presence of respiratory symptoms. In contrast to previous studies, smoking per se was not significantly associated with urinary BRP levels.
KW - Asthma
KW - Bombesin-related peptides
KW - Chronic bronchitis
KW - Chronic obstructive pulmonary disease prevalence
KW - Pulmonary neuroendocrine cells
KW - Tobacco smoke
UR - http://www.scopus.com/inward/record.url?scp=0031978063&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031978063&partnerID=8YFLogxK
U2 - 10.1097/00000441-199804000-00008
DO - 10.1097/00000441-199804000-00008
M3 - Article
VL - 315
SP - 258
EP - 265
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 4
ER -