Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)

Natalia Bravo, Joan O. Grimalt, Beatrice Bocca, Anna Pino, Maura Bin, Liza Vecchi Brumatti, Valentina Rosolen, Fabio Barbone, Luca Ronfani, Alessandro Alimonti, Gemma Calamandrei

Research output: Contribution to journalArticlepeer-review


Urinary metabolites of organophosphate (OP) and pyrethroid (PYR) pesticides from seven years old children of a birth cohort study (n=199; PHIME cohort of Trieste, Italy) have been measured. Six OP and two PYR metabolites have been investigated, 2-diethylamino-6-methylpyrimidin-4-ol (DEAMPY, pirimiphos metabolite) was the one found at higher concentrations, median 3.4 ng/mL specific gravity adjusted (SG adjusted), followed by 4-nitrophenol (PNP, median 1.4 ng/mL SG adjusted) and 3,5,6-trichloro-2-pyridinol (TCPY, median 0.36 ng/mL SG adjusted), parathion and chlorpyriphos metabolites, respectively. TCPY concentrations were low in comparison to other distributions of OP metabolites in children from other studies. Accordingly, the PHIME cohort showed a distinct OP metabolite distribution with high concentrations of pirimiphos and parathion. Another specific characteristic of this cohort was the high concentration of 3-phenoxybenzoic acid (3-BPA, median 0.36 ng/mL SG adjusted), a general metabolite of PYR pesticides. Evaluation of anthropometric and socio-demographic characteristics of children and families only showed a positive association between family educational level and urinary concentrations of DEAMPY metabolite (p<0.05), which could reflect distinct dietary habits depending on the educational level. Estimated daily intakes were evaluated, all studied metabolites were found within safe levels.

Original languageEnglish
Article number108508
JournalEnvironmental Research
Publication statusPublished - Sep 2019


  • Children
  • Estimated daily intakes
  • Human biomonitoring
  • Organophosphate pesticides
  • Pyrethroids

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)


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