Urinary metabolomics of bronchopulmonary dysplasia (BPD): Preliminary data at birth suggest it is a congenital disease

Vassilios Fanos, Maria Cristina Pintus, Milena Lussu, Luigi Atzori, Antonio Noto, Mauro Stronati, Hercilia Guimaraes, Maria Antonietta Marcialis, Gustavo Rocha, Corrado Moretti, Paola Papoff, Serafina Lacerenza, Silvia Puddu, Mario Giuffrè, Francesca Serraino, Michele Mussap, Giovanni Corsello

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: Bronchopulmonary dysplasia (BPD) or chronic lung disease is one of the principal causes of mortality and morbidity in preterm infants. Early identification of infants at the greater risk of developing BPD may allow a targeted approach for reducing disease severity and complications. The trigger cause of the disease comprehends the impairment of the alveolar development and the increased angiogenesis. Nevertheless, the molecular pathways characterizing the disease are still unclear. Therefore, the use of the metabolomics technique, due to the capability of identifying instantaneous metabolic perturbation, might help to recognize metabolic patterns associated with the condition.

Methods: The purpose of this study is to compare urinary metabolomics at birth in 36 newborns with a gestational age below 29 weeks and birth weight

Results: The 1H-NMR spectra were analyzed using a partial least squares discriminant analysis (PLS-DA) model coupled with orthogonal Signal Correction. Using this approach it was possible with urine at birth to discriminate newborns that will be later have a diagnosis of BPD with a high statistics power. In particular, we found five important discriminant metabolites in urine in BPD newborns: lactate, taurine, TMAO, myoinositol (which increased) and gluconate (which decreased).

Conclusion: These preliminary results seem to be promising for the identification of predictor's biomarkers characterizing the BPD condition. These data may suggest that BPD is probably the result of an abnormal development (respiratory bud, vascular tree, hypodysplasia of pneumocytes) and could be considered a congenital disease (genetics plus intrauterine epigenetics). Early identification of infants at the greater risk of developing BPD may allow a targeted approach for reducing disease severity and complications.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume27
DOIs
Publication statusPublished - Oct 1 2014

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Bronchopulmonary Dysplasia
Metabolomics
Parturition
Newborn Infant
Urine
Alveolar Epithelial Cells
Inborn Genetic Diseases
Taurine
Discriminant Analysis
Inositol
Least-Squares Analysis
Birth Weight
Epigenomics
Premature Infants
Lung Diseases
Gestational Age
Blood Vessels
Lactic Acid
Chronic Disease
Biomarkers

Keywords

  • H-NMR
  • Bronchopulmonary dysplasia
  • Metabolites
  • Metabolomics
  • Multivariate statistical analysis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology
  • Medicine(all)

Cite this

Urinary metabolomics of bronchopulmonary dysplasia (BPD) : Preliminary data at birth suggest it is a congenital disease. / Fanos, Vassilios; Cristina Pintus, Maria; Lussu, Milena; Atzori, Luigi; Noto, Antonio; Stronati, Mauro; Guimaraes, Hercilia; Marcialis, Maria Antonietta; Rocha, Gustavo; Moretti, Corrado; Papoff, Paola; Lacerenza, Serafina; Puddu, Silvia; Giuffrè, Mario; Serraino, Francesca; Mussap, Michele; Corsello, Giovanni.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 27, 01.10.2014, p. 39-45.

Research output: Contribution to journalArticle

Fanos, V, Cristina Pintus, M, Lussu, M, Atzori, L, Noto, A, Stronati, M, Guimaraes, H, Marcialis, MA, Rocha, G, Moretti, C, Papoff, P, Lacerenza, S, Puddu, S, Giuffrè, M, Serraino, F, Mussap, M & Corsello, G 2014, 'Urinary metabolomics of bronchopulmonary dysplasia (BPD): Preliminary data at birth suggest it is a congenital disease', Journal of Maternal-Fetal and Neonatal Medicine, vol. 27, pp. 39-45. https://doi.org/10.3109/14767058.2014.955966
Fanos, Vassilios ; Cristina Pintus, Maria ; Lussu, Milena ; Atzori, Luigi ; Noto, Antonio ; Stronati, Mauro ; Guimaraes, Hercilia ; Marcialis, Maria Antonietta ; Rocha, Gustavo ; Moretti, Corrado ; Papoff, Paola ; Lacerenza, Serafina ; Puddu, Silvia ; Giuffrè, Mario ; Serraino, Francesca ; Mussap, Michele ; Corsello, Giovanni. / Urinary metabolomics of bronchopulmonary dysplasia (BPD) : Preliminary data at birth suggest it is a congenital disease. In: Journal of Maternal-Fetal and Neonatal Medicine. 2014 ; Vol. 27. pp. 39-45.
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AU - Fanos, Vassilios

AU - Cristina Pintus, Maria

AU - Lussu, Milena

AU - Atzori, Luigi

AU - Noto, Antonio

AU - Stronati, Mauro

AU - Guimaraes, Hercilia

AU - Marcialis, Maria Antonietta

AU - Rocha, Gustavo

AU - Moretti, Corrado

AU - Papoff, Paola

AU - Lacerenza, Serafina

AU - Puddu, Silvia

AU - Giuffrè, Mario

AU - Serraino, Francesca

AU - Mussap, Michele

AU - Corsello, Giovanni

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N2 - Objective: Bronchopulmonary dysplasia (BPD) or chronic lung disease is one of the principal causes of mortality and morbidity in preterm infants. Early identification of infants at the greater risk of developing BPD may allow a targeted approach for reducing disease severity and complications. The trigger cause of the disease comprehends the impairment of the alveolar development and the increased angiogenesis. Nevertheless, the molecular pathways characterizing the disease are still unclear. Therefore, the use of the metabolomics technique, due to the capability of identifying instantaneous metabolic perturbation, might help to recognize metabolic patterns associated with the condition.Methods: The purpose of this study is to compare urinary metabolomics at birth in 36 newborns with a gestational age below 29 weeks and birth weight Results: The 1H-NMR spectra were analyzed using a partial least squares discriminant analysis (PLS-DA) model coupled with orthogonal Signal Correction. Using this approach it was possible with urine at birth to discriminate newborns that will be later have a diagnosis of BPD with a high statistics power. In particular, we found five important discriminant metabolites in urine in BPD newborns: lactate, taurine, TMAO, myoinositol (which increased) and gluconate (which decreased).Conclusion: These preliminary results seem to be promising for the identification of predictor's biomarkers characterizing the BPD condition. These data may suggest that BPD is probably the result of an abnormal development (respiratory bud, vascular tree, hypodysplasia of pneumocytes) and could be considered a congenital disease (genetics plus intrauterine epigenetics). Early identification of infants at the greater risk of developing BPD may allow a targeted approach for reducing disease severity and complications.

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KW - Metabolomics

KW - Multivariate statistical analysis

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