Urinary N-acetyl-beta-D-glucosaminidase concentration in patients with spinal cord injury: Relationship with urodynamic parameters

Enrico Finazzi Agrò, Salvatore Micali, Mauro Maccarrone, Andrea D'Amico, Giuseppe Vespasiani, Patrizio Pasqualetti, Carlo Caltagirone

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives. To investigate the relationships between urinary N-acetyl-beta-D-glucosaminidase (NAG) concentrations and urodynamic parameters in patients with spinal cord injury (SCI). NAG has been proposed as a marker of renal damage. Methods. Twenty-three patients with SCI were evaluated with urodynamic studies. Urine samples were collected from the 23 patients and 10 healthy volunteers, the NAG levels were evaluated, and the urodynamic parameters were compared with the urinary NAG levels. The patients were divided into two groups according to the amplitude of the hyperreflexic detrusor contractions (HDCs): group A, patients with an HDC amplitude of 40 cm H2O or greater, and group B, patients with an HDC amplitude of less than 40 cm H2O; group C was composed of healthy volunteers. The urinary NAG concentrations in the three groups were compared. Results. A positive correlation was found between the urinary NAG levels and the HDC amplitude and detrusor leak point pressure (P = 0.015 and 0.007, respectively). The urinary NAG concentration was 3.38 U/g in group A, 2.14 U/g in group B, and 2.12 U/g in group C. The differences in the urinary NAG concentrations between groups A and B and between groups A and C were statistically significant (P = 0.03 and P

Original languageEnglish
Pages (from-to)870-874
Number of pages5
JournalUrology
Volume58
Issue number6
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Urology

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