Urinary neutrophil gelatinase-associated lipocalin at birth predicts early renal function in very low birth weight infants

Gaetano La Manna, Silvia Galletti, Irene Capelli, Silvia Vandini, Katia Nisi, Giulia Aquilano, Rita Mancini, Elisa Carretta, Giovanni Montini, Giacomo Faldella, Sergio Stefoni

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Abstract

Preterm infants are exposed to conditions that can impair renal function. We evaluated the ability of serum and urinary neutrophil gelatinase-associated lipocalin (sNGAL and uNGAL) to predict renal function in the first weeks of life. From September 2008 to July 2009, infants weighing ≤1500 g at birth with no major congenital anomalies or sepsis were eligible. We measured sNGAL and uNGAL levels at birth. To evaluate renal function, we determined changes in serum creatinine (sCreat) and estimated GFR (eGFR) from birth to d 21. Forty neonates (mean GA, 27 ± 2 wk) completed the study. Renal function improved in 32 of 40 (80%) infants (normal renal function, NRF group) (sCreat, from 0.97 ± 0.2 to 0.53 ± 0.13 mg/dL; eGFR, from 15.3 ± 4.1 to 28.6 ± 7.9 mL/min), whereas renal function worsened in 8 of 40 (20%) infants (impaired renal function, IRF group) (sCreat, from 0.71 ± 0.27 to 0.98 ± 0.43 mg/dL; eGFR from 23 ± 14.7 to 16.4 ± 9.1 mL/min). The uNGAL/urinary creatinine (uCreat) ratio at birth was higher in the IRF group (31.05 ng/mg) than the NRF group (6.0 ng/mg), and uNGAL was significantly higher in IRF group, detecting IRF with a cutoff of 100 ng/mL. uNGAL levels at birth may have a predictive role in very LBW (VLBW) infants.

Original languageEnglish
Pages (from-to)379-383
Number of pages5
JournalPediatric Research
Volume70
Issue number4
DOIs
Publication statusPublished - Oct 2011

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Very Low Birth Weight Infant
Parturition
Kidney
Creatinine
Serum
Lipocalin-2
Premature Infants
Sepsis
Newborn Infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Urinary neutrophil gelatinase-associated lipocalin at birth predicts early renal function in very low birth weight infants. / La Manna, Gaetano; Galletti, Silvia; Capelli, Irene; Vandini, Silvia; Nisi, Katia; Aquilano, Giulia; Mancini, Rita; Carretta, Elisa; Montini, Giovanni; Faldella, Giacomo; Stefoni, Sergio.

In: Pediatric Research, Vol. 70, No. 4, 10.2011, p. 379-383.

Research output: Contribution to journalArticle

La Manna, G, Galletti, S, Capelli, I, Vandini, S, Nisi, K, Aquilano, G, Mancini, R, Carretta, E, Montini, G, Faldella, G & Stefoni, S 2011, 'Urinary neutrophil gelatinase-associated lipocalin at birth predicts early renal function in very low birth weight infants', Pediatric Research, vol. 70, no. 4, pp. 379-383. https://doi.org/10.1203/PDR.0b013e31822941c7
La Manna, Gaetano ; Galletti, Silvia ; Capelli, Irene ; Vandini, Silvia ; Nisi, Katia ; Aquilano, Giulia ; Mancini, Rita ; Carretta, Elisa ; Montini, Giovanni ; Faldella, Giacomo ; Stefoni, Sergio. / Urinary neutrophil gelatinase-associated lipocalin at birth predicts early renal function in very low birth weight infants. In: Pediatric Research. 2011 ; Vol. 70, No. 4. pp. 379-383.
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AU - Nisi, Katia

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