Urinary p-cresol is elevated in small children with severe autism spectrum disorder

Laura Altieri, Cristina Neri, Roberto Sacco, Paolo Curatolo, Arianna Benvenuto, Filippo Muratori, Elisa Santocchi, Carmela Bravaccio, Carlo Lenti, Monica Saccani, Roberto Rigardetto, Marina Gandione, Andrea Urbani, Antonio M. Persico

Research output: Contribution to journalArticlepeer-review

Abstract

Several studies have described in autistic patients an overgrowth of unusual gut bacterial strains, able to push the fermentation of tyrosine up to the formation of p-cresol. We compared levels of urinary p-cresol, measured by high-performance liquid chromatography-ultraviolet, in 59 matched case-control pairs. Urinary p-cresol was significantly elevated in autistic children smaller than 8 years of age (p

Original languageEnglish
Pages (from-to)252-260
Number of pages9
JournalBiomarkers
Volume16
Issue number3
DOIs
Publication statusPublished - May 2011

Keywords

  • Clostridium
  • cotinine
  • gut flora
  • organic contaminants
  • pervasive developmental disorders

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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