Urinary p-cresol is elevated in young French children with autism spectrum disorder: A replication study

Stefano Gabriele, Roberto Sacco, Sonia Cerullo, Cristina Neri, Andrea Urbani, Gabriele Tripi, Joëlle Malvy, Catherine Barthelemy, Frédérique Bonnet-Brihault, Antonio M. Persico

Research output: Contribution to journalArticlepeer-review

Abstract

The aromatic compound p-cresol (4-methylphenol) has been found elevated in the urines of Italian autistic children up to 8 years of age. The present study aims at replicating these initial findings in an ethnically distinct sample and at extending them by measuring also the three components of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol. Total urinary p-cresol, p-cresylsulfate and p-cresylglucuronate were significantly elevated in 33 French autism spectrum disorder (ASD) cases compared with 33 sex- and age-matched controls (p

Original languageEnglish
Pages (from-to)463-470
Number of pages8
JournalBiomarkers
Volume19
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • Gut flora
  • Neurotoxicity
  • Organic contaminants
  • p-cresylsulfate
  • Pervasive developmental disorders

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

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