Urinary RNA-based biomarkers for prostate cancer detection

Filippo Martignano, Lorena Rossi, Antonio Maugeri, Valentina Gallà, Vincenza Conteduca, Ugo De Giorgi, Valentina Casadio, Giuseppe Schepisi

Research output: Contribution to journalReview article

Abstract

Prostate cancer (PCa) is the commonest malignancy in the male population worldwide. Serum prostate specific antigen (PSA) test is the most important biomarker for the detection, follow-up and therapeutic monitoring of PCa. Defects in PSA specificity have elicited research for new biomarkers to improve early diagnosis and avoid false-positive results. This review evaluates urinary RNA-based biomarkers. Urine is a versatile body fluid for non-invasive biomarker detection in case of urological malignancies. The importance of RNA-based biomarkers has been demonstrated by the current use of PCA3, a long non coding RNA biomarker already approved by the Food and Drugs Administration. Through the years, other urinary RNA biomarkers have been evaluated, including the well-known TMPRSS2:ERG transcript, as well as many messenger RNAs, long non coding RNAs and micro-RNA. Validation of a specific urinary RNA-based marker or an algorithm of different biomarkers levels as diagnostic markers for PCa could be useful to avoid unnecessary prostate biopsies.

Original languageEnglish
Pages (from-to)96-105
Number of pages10
JournalClinica Chimica Acta
Volume473
DOIs
Publication statusPublished - Oct 1 2017

Fingerprint

Biomarkers
Prostatic Neoplasms
RNA
Long Noncoding RNA
Prostate-Specific Antigen
Biopsy
Body fluids
Body Fluids
United States Food and Drug Administration
MicroRNAs
Prostate
Early Diagnosis
Neoplasms
Urine
Messenger RNA
Defects
Monitoring
Serum
Research
Population

Keywords

  • Biomarkers
  • lncRNA
  • miRNA
  • mRNA
  • Prostate cancer
  • RNA
  • Urine

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Urinary RNA-based biomarkers for prostate cancer detection. / Martignano, Filippo; Rossi, Lorena; Maugeri, Antonio; Gallà, Valentina; Conteduca, Vincenza; De Giorgi, Ugo; Casadio, Valentina; Schepisi, Giuseppe.

In: Clinica Chimica Acta, Vol. 473, 01.10.2017, p. 96-105.

Research output: Contribution to journalReview article

Martignano, Filippo ; Rossi, Lorena ; Maugeri, Antonio ; Gallà, Valentina ; Conteduca, Vincenza ; De Giorgi, Ugo ; Casadio, Valentina ; Schepisi, Giuseppe. / Urinary RNA-based biomarkers for prostate cancer detection. In: Clinica Chimica Acta. 2017 ; Vol. 473. pp. 96-105.
@article{bfdc44d8a3b24950b1ed8f43d9366d16,
title = "Urinary RNA-based biomarkers for prostate cancer detection",
abstract = "Prostate cancer (PCa) is the commonest malignancy in the male population worldwide. Serum prostate specific antigen (PSA) test is the most important biomarker for the detection, follow-up and therapeutic monitoring of PCa. Defects in PSA specificity have elicited research for new biomarkers to improve early diagnosis and avoid false-positive results. This review evaluates urinary RNA-based biomarkers. Urine is a versatile body fluid for non-invasive biomarker detection in case of urological malignancies. The importance of RNA-based biomarkers has been demonstrated by the current use of PCA3, a long non coding RNA biomarker already approved by the Food and Drugs Administration. Through the years, other urinary RNA biomarkers have been evaluated, including the well-known TMPRSS2:ERG transcript, as well as many messenger RNAs, long non coding RNAs and micro-RNA. Validation of a specific urinary RNA-based marker or an algorithm of different biomarkers levels as diagnostic markers for PCa could be useful to avoid unnecessary prostate biopsies.",
keywords = "Biomarkers, lncRNA, miRNA, mRNA, Prostate cancer, RNA, Urine",
author = "Filippo Martignano and Lorena Rossi and Antonio Maugeri and Valentina Gall{\`a} and Vincenza Conteduca and {De Giorgi}, Ugo and Valentina Casadio and Giuseppe Schepisi",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.cca.2017.08.009",
language = "English",
volume = "473",
pages = "96--105",
journal = "Clinica Chimica Acta",
issn = "0009-8981",
publisher = "Elsevier",

}

TY - JOUR

T1 - Urinary RNA-based biomarkers for prostate cancer detection

AU - Martignano, Filippo

AU - Rossi, Lorena

AU - Maugeri, Antonio

AU - Gallà, Valentina

AU - Conteduca, Vincenza

AU - De Giorgi, Ugo

AU - Casadio, Valentina

AU - Schepisi, Giuseppe

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Prostate cancer (PCa) is the commonest malignancy in the male population worldwide. Serum prostate specific antigen (PSA) test is the most important biomarker for the detection, follow-up and therapeutic monitoring of PCa. Defects in PSA specificity have elicited research for new biomarkers to improve early diagnosis and avoid false-positive results. This review evaluates urinary RNA-based biomarkers. Urine is a versatile body fluid for non-invasive biomarker detection in case of urological malignancies. The importance of RNA-based biomarkers has been demonstrated by the current use of PCA3, a long non coding RNA biomarker already approved by the Food and Drugs Administration. Through the years, other urinary RNA biomarkers have been evaluated, including the well-known TMPRSS2:ERG transcript, as well as many messenger RNAs, long non coding RNAs and micro-RNA. Validation of a specific urinary RNA-based marker or an algorithm of different biomarkers levels as diagnostic markers for PCa could be useful to avoid unnecessary prostate biopsies.

AB - Prostate cancer (PCa) is the commonest malignancy in the male population worldwide. Serum prostate specific antigen (PSA) test is the most important biomarker for the detection, follow-up and therapeutic monitoring of PCa. Defects in PSA specificity have elicited research for new biomarkers to improve early diagnosis and avoid false-positive results. This review evaluates urinary RNA-based biomarkers. Urine is a versatile body fluid for non-invasive biomarker detection in case of urological malignancies. The importance of RNA-based biomarkers has been demonstrated by the current use of PCA3, a long non coding RNA biomarker already approved by the Food and Drugs Administration. Through the years, other urinary RNA biomarkers have been evaluated, including the well-known TMPRSS2:ERG transcript, as well as many messenger RNAs, long non coding RNAs and micro-RNA. Validation of a specific urinary RNA-based marker or an algorithm of different biomarkers levels as diagnostic markers for PCa could be useful to avoid unnecessary prostate biopsies.

KW - Biomarkers

KW - lncRNA

KW - miRNA

KW - mRNA

KW - Prostate cancer

KW - RNA

KW - Urine

UR - http://www.scopus.com/inward/record.url?scp=85028328485&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028328485&partnerID=8YFLogxK

U2 - 10.1016/j.cca.2017.08.009

DO - 10.1016/j.cca.2017.08.009

M3 - Review article

AN - SCOPUS:85028328485

VL - 473

SP - 96

EP - 105

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

ER -