Urinary S100A1B and S100BB to predict hypoxic ischemic encephalopathy at term

Moataza Bashir, Alessandro Frigiola, Iman Iskander, Hala Mufeed Said, Hanna Aboulgar, Rosanna Frulio, Pierluigi Bruschettini, Fabrizio Michetti, Pasquale Florio, Serena Pinzauti, Raul Abella, Michele Mussap, Diego Gazzolo

Research output: Contribution to journalArticlepeer-review


Urinary S100A1B and S100BB were measured to detect cases at risk of hypoxic-ischemic encephalopathy (HIE) in asphyxiated newborns. We recruited 42 asphyxiated infants and 63 healthy term neonates. S100A1B and S100BB were measured at first urination (time 0) and at 4 (time 1), 8 (time 2), 12 (time 3), 16 (time 4), 20 (time 5), 24 (time 6), 72 (time 7) hours after birth. 20 infants had no/mild HIE with good prognosis (Group A) and 22 had moderate/severe HIE with a greater risk of neurological handicap (Group B). Urine S100A1B and S100BB levels were significantly (P less than 0.0.01, for all) higher at all monitoring time-points in Group B than Group A and controls, but not between Group A and controls. Both S100A1B and S100BB have great sensitivity and specificity for HIE since their first measurement. In conclusion, S100A1B and S100BB are increased in urine collected from asphyxiated newborns who will develop HIE since first urination, and their measurement may be useful to early predict HIE when monitoring procedures are still of no avail.

Original languageEnglish
Pages (from-to)560-567
Number of pages8
JournalFrontiers in Bioscience - Elite
Volume1 E
Issue number2
Publication statusPublished - Jun 1 2009


  • Asphyxia
  • Neonatal death
  • Newborns
  • S100 protein

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)


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