Urinary strong ion difference as a marker of renal dysfunction. A retrospective analysis

Paolo Balsorano, Stefano Romagnoli, Samuel Kagan Evans, Zaccaria Ricci, Angelo Raffaele De Gaudio

Research output: Contribution to journalArticle

Abstract

Introduction: The kidneys play a crucial role in the regulation of electrolytes and acid-base homeostasis. Urinary Strong Ion Difference (SIDu = NaU + KU - ClU) represents an important aspect of renal acid-base regulation. We evaluated the role of SIDu as a marker of renal dysfunction in critically ill patients. Materials and Methods: Patients admitted to the Medical Intensive Care Unit with a diagnosis of AKI for whom concomitant urinary samples available for SIDu calculation were retrospectively reviewed and staged according to KDIGO criteria for 3 days from inclusion. Patients were classified as Recovered (R-AKI) or Persistent-AKI (P-AKI) whether they exited KDIGO criteria within the 3-day observation period or not. A control group with normal renal function and normal serum acid-base and electrolytes was prospectively recruited in order to identify reference SIDu values. Results: One-hundred-and-forty-three patients with a diagnosis of AKI were included: 77 with R-AKI, and 66 with P-AKI. Thirty-six controls were recruited. Patients with P-AKI had more severe renal dysfunction and higher mortality than patients with R-AKI (SCr 2.23(IQR:1.68-3.45) and 1.81(IQR1.5-2.5) mg/dl respectively, p

Original languageEnglish
Article numbere0156941
JournalPLoS One
Volume11
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

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kidneys
Ions
ions
Kidney
Electrolytes
Acids
Intensive care units
electrolytes
acids
renal function
Critical Illness
normal values
Intensive Care Units
homeostasis
Reference Values
Homeostasis
Observation
Control Groups
Mortality
Serum

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Urinary strong ion difference as a marker of renal dysfunction. A retrospective analysis. / Balsorano, Paolo; Romagnoli, Stefano; Evans, Samuel Kagan; Ricci, Zaccaria; De Gaudio, Angelo Raffaele.

In: PLoS One, Vol. 11, No. 6, e0156941, 01.06.2016.

Research output: Contribution to journalArticle

Balsorano, Paolo ; Romagnoli, Stefano ; Evans, Samuel Kagan ; Ricci, Zaccaria ; De Gaudio, Angelo Raffaele. / Urinary strong ion difference as a marker of renal dysfunction. A retrospective analysis. In: PLoS One. 2016 ; Vol. 11, No. 6.
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