Urinary tract dysfunction in multiple sclerosis: Is there a relation with disease-related parameters?

D. Porru, G. Campus, A. Garau, M. Sorgia, A. C. Pau, G. Spinici, M. P. Pischedda, M. G. Marrosu, R. M. Scarpa, E. Usai

Research output: Contribution to journalArticlepeer-review


The lower urinary tract is affected by multiple sclerosis in many patients. We screened urologically and neurologically 120 patients with a confirmed diagnosis of multiple sclerosis. The mean age was 42 years (range 22 to 69 years). Urodynamic investigation as well as neuro-urophysiological investigations were performed in all patients. Renal ultrasound was used to study morphology, and excretory urogram (IVU) was used to assess renal function and the upper urinary tracts in 105 patients. Obstructive symptoms were found more commonly than irritative symptoms. The urinary symptoms were found to be related to disease duration and not to disability status. Urodynamic abnormalities were statistically significantly related to disease duration (X2 = 38.51; P = 0.0001), and to the disability status (X2 = 76.70; P = 0.0001). Few patients, only 3.3%, had upper urinary tract dilatation. With medical management, hydronephrosis disappeared in all of the patients and did not recur. A combination of oral pharmacological agents and clean intermittent catheterization was used in the majority of the patients. We conclude that lower urodynamic abnormalities can be present in every patient with multiple sclerosis, and appear to be related to disease duration and disability status, thus early treatment based upon urodynamic evaluation and close follow-up can reduce morbidity and improve the quality of life.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalSpinal Cord
Issue number1
Publication statusPublished - 1997


  • Multiple sclerosis
  • Neuropathic bladder
  • Urinary tract abnormalities

ASJC Scopus subject areas

  • Clinical Neurology


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