Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage

Sara Santambrogio, Angela Cattaneo, Ilenia Bernascone, Thomas Schwend, Luca Jovine, Angela Bachi, Luca Rampoldi

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Uromodulin (or Tamm-Horsfall protein) is the most abundant protein in human urine under physiological conditions. Little is known about the molecular mechanism of uromodulin secretion. By extensive Mass Spectrometry analyses we mapped the C-termini of human and murine urinary proteins demonstrating that urinary uromodulin is generated by a conserved C-terminal proteolytic cleavage and retains its entire ZP domain.

Original languageEnglish
Pages (from-to)410-413
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume370
Issue number3
DOIs
Publication statusPublished - Jun 6 2008

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Uromodulin
Mass spectrometry
Mass Spectrometry
Proteins
Urine

Keywords

  • Mass Spectrometry
  • Uromodulin
  • Zona pellucida domain

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage. / Santambrogio, Sara; Cattaneo, Angela; Bernascone, Ilenia; Schwend, Thomas; Jovine, Luca; Bachi, Angela; Rampoldi, Luca.

In: Biochemical and Biophysical Research Communications, Vol. 370, No. 3, 06.06.2008, p. 410-413.

Research output: Contribution to journalArticle

Santambrogio, Sara ; Cattaneo, Angela ; Bernascone, Ilenia ; Schwend, Thomas ; Jovine, Luca ; Bachi, Angela ; Rampoldi, Luca. / Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage. In: Biochemical and Biophysical Research Communications. 2008 ; Vol. 370, No. 3. pp. 410-413.
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AU - Bachi, Angela

AU - Rampoldi, Luca

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