TY - JOUR
T1 - Urokinase expression in course of benign and malignant mammary lesions
T2 - Comparison between nodular and healthy tissues
AU - Ceccarelli, Francesca
AU - Fuso, Andrea
AU - Civitelli, Liana
AU - Ranieri, Ersilia
AU - Caprio, Giuliana
AU - Pagni, Paola
AU - Rengo, Mario
AU - Scarpa, Sigfrido
PY - 2010/1
Y1 - 2010/1
N2 - Purpose: Increased expression of urokinase (uPA), a member of the serine protease family, is an effector of metastatic cascade and has been reported in various malignancies, including breast cancer. uPA overexpression in cancer tissues was correlated with a more aggressive phenotype and it is considered a strong and independent unfavorable prognostic factor in breast cancer. Methods: Using real-time PCR assay, we analyzed uPA expression of malignant and benign breast nodular lesions versus healthy tissues (normal breast and lymphocytes). Results: We found that besides breast cancer nodule, normal mammary gland and lymphocytes overexpressed uPA too. Tissues obtained from women with benign lesions expressed homogeneous and lower uPA. Conclusions: In conclusion, although uPA overexpression is typical of cancer tissues, it could be considered as a feature of the whole organism affected by cancer. On the basis of these first results, uPA could be considered for further studies as a possible useful therapeutic target in breast cancer.
AB - Purpose: Increased expression of urokinase (uPA), a member of the serine protease family, is an effector of metastatic cascade and has been reported in various malignancies, including breast cancer. uPA overexpression in cancer tissues was correlated with a more aggressive phenotype and it is considered a strong and independent unfavorable prognostic factor in breast cancer. Methods: Using real-time PCR assay, we analyzed uPA expression of malignant and benign breast nodular lesions versus healthy tissues (normal breast and lymphocytes). Results: We found that besides breast cancer nodule, normal mammary gland and lymphocytes overexpressed uPA too. Tissues obtained from women with benign lesions expressed homogeneous and lower uPA. Conclusions: In conclusion, although uPA overexpression is typical of cancer tissues, it could be considered as a feature of the whole organism affected by cancer. On the basis of these first results, uPA could be considered for further studies as a possible useful therapeutic target in breast cancer.
KW - Benign breast lesions
KW - Breast cancer
KW - Lymphocytes
KW - MRNA analysis
KW - Urokinase (uPA)
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U2 - 10.1007/s00432-009-0694-1
DO - 10.1007/s00432-009-0694-1
M3 - Article
C2 - 19826838
AN - SCOPUS:71449116112
VL - 136
SP - 157
EP - 163
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
SN - 0171-5216
IS - 1
ER -