Urokinase plasminogen activator receptor in adipose tissue macrophages of morbidly obese subjects

Raffaella Cancello, Christine Rouault, Gaël Guilhem, Jean François Bedel, Christine Poitou, Anna Maria Di Blasio, Arnaud Basdevant, Joan Tordjman, Karine Clément

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: At present, circulating markers characterizing the inflammatory infiltration of white adipose tissue (WAT) in human obesity are not well known. We previously identified, by a pangenomic approach (microarrays), the urokinase plasminogen activator receptor (PLAUR or CD87) as a potential marker of subcutaneous adipose tissue macrophage infiltration (ATM). Method: We studied i) the presence of PLAUR protein in WAT; ii) the PLAUR amount in plasma of obese patients; iii) the circulating variations during surgery-induced weight loss, and iv) the correlations between PLAUR circulating levels and bioclinical parameters. Results: We observed that PLAUR is preferentially expressed by infiltrating ATMs, with a typical localization on macrophage membrane. Circulating soluble PLAUR levels were significantly elevated in obese patients compared to lean controls. However, despite a trend towards a decrease 3 months after weight loss, PLAUR plasma levels were not modulated during a 1-year weight loss follow-up, suggesting the contribution of secretion sites other than subcutaneous WAT in obese patients. Conclusions: These findings indicate that PLAUR mRNA expression could be used for the estimation of local subcutaneous ATMs infiltration in obese patients, but it cannot be used as a systemic marker of this inflammatory infiltration in dynamic phases of weight loss.

Original languageEnglish
Pages (from-to)17-25
Number of pages9
JournalObesity Facts
Volume4
Issue number1
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Adipocytes
  • CD87
  • Inflammation
  • Macrophages
  • Obesity
  • PLAUR
  • Urokinase plasminogen activator receptor
  • White adipose tissue

ASJC Scopus subject areas

  • Physiology (medical)
  • Health(social science)

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