Abstract
Objective: At present, circulating markers characterizing the inflammatory infiltration of white adipose tissue (WAT) in human obesity are not well known. We previously identified, by a pangenomic approach (microarrays), the urokinase plasminogen activator receptor (PLAUR or CD87) as a potential marker of subcutaneous adipose tissue macrophage infiltration (ATM). Method: We studied i) the presence of PLAUR protein in WAT; ii) the PLAUR amount in plasma of obese patients; iii) the circulating variations during surgery-induced weight loss, and iv) the correlations between PLAUR circulating levels and bioclinical parameters. Results: We observed that PLAUR is preferentially expressed by infiltrating ATMs, with a typical localization on macrophage membrane. Circulating soluble PLAUR levels were significantly elevated in obese patients compared to lean controls. However, despite a trend towards a decrease 3 months after weight loss, PLAUR plasma levels were not modulated during a 1-year weight loss follow-up, suggesting the contribution of secretion sites other than subcutaneous WAT in obese patients. Conclusions: These findings indicate that PLAUR mRNA expression could be used for the estimation of local subcutaneous ATMs infiltration in obese patients, but it cannot be used as a systemic marker of this inflammatory infiltration in dynamic phases of weight loss.
Original language | English |
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Pages (from-to) | 17-25 |
Number of pages | 9 |
Journal | Obesity Facts |
Volume | 4 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 2011 |
Keywords
- Adipocytes
- CD87
- Inflammation
- Macrophages
- Obesity
- PLAUR
- Urokinase plasminogen activator receptor
- White adipose tissue
ASJC Scopus subject areas
- Physiology (medical)
- Health(social science)