Urokinase-type plasminogen activator

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Urokinase-type plasminogen activator (uPA) is a serine protease involved in tissue remodeling and cell migration. At the gene level, the interplay between a complex enhancer, required for induced and basal transcription, and the minimal promoter finely tunes uPA expression. The active form of uPA is bound to its high affinity receptor on the cell surface, where specific inhibitors modulate its enzymatic activity. Such inhibitors also regulate the cell surface levels of uPA by triggering the internalization of the uPA-receptor-inhibitor complex. The role of uPA is not only linked to its action as an enzyme. In fact, the mere binding of uPA on the cell surface also brings about two events that broaden the spectrum of its biological functions: (1) a conformational change of the receptor, which, in turn, affects its interaction with other proteins; (2) a signal transduction which modulates the expression of apoptosis-related genes. Besides its applications as a thrombolytic agent and as a prognostic marker for tumors, uPA may provide the basis for other therapies, as the structure of the receptor-binding domain of uPA has become a model for the design of anti-cancer molecules.

Original languageEnglish
Pages (from-to)690-694
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume39
Issue number4
DOIs
Publication statusPublished - 2007

Fingerprint

Urokinase-Type Plasminogen Activator
Genes
Urokinase Plasminogen Activator Receptors
Plasminogen Inactivators
Signal transduction
Fibrinolytic Agents
Cell Surface Receptors
Serine Proteases
Transcription
Tumor Biomarkers
Cell Movement
Signal Transduction
Tissue
Apoptosis
Molecules
Enzymes

Keywords

  • cell migration
  • Extracellular matrix
  • Tissue remodeling
  • Urokinase-type plasminogen activator
  • Urokinase-type plasminogen activator receptor

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Urokinase-type plasminogen activator. / Crippa, Massimo P.

In: International Journal of Biochemistry and Cell Biology, Vol. 39, No. 4, 2007, p. 690-694.

Research output: Contribution to journalArticle

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