Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions

Roberto Sala, Pedro Mena, Monia Savi, Furio Brighenti, Alan Crozier, Michele Miragoli, Donatella Stilli, Daniele Del Rio

Research output: Contribution to journalArticle

Abstract

Diabetic cardiomyopathy (DCM) develops independently of common cardiovascular co-morbidities and is initiated by the metabolic derangements accompanying diabetes mellitus, including hyperglycaemia, which may cause a mild inflammatory state able to negatively affect myocardial biochemistry, structure, and function. This work shows how different urolithins, ellagitannin-derived metabolites, were able to modulate the pro-inflammatory mediators and growth factors secreted by rat cardiac myocytes and fibroblasts exposed to high glucose concentrations. At 1 μM concentration, coherent with dietary exposure to ellagitannin-rich foods, urolithins B and B-glucuronide succeeded in preventing inflammatory responses in cardiomyocytes, while in fibroblasts urolithin D was the most effective in controlling the overexpression of fractalkine, among the tested inflammatory mediators. Urolithins underwent extensive biotransformations in both cell types, including (de)glucuronidation, methylation, and sulphation. This suggests that the inflammatory bulk produced by hyperglycaemia could be attenuated by the regular intake of ellagitannin-rich foodstuffs such as pomegranates, raspberries, blackberries, strawberries, and walnuts.

Original languageEnglish
Pages (from-to)97-105
Number of pages9
JournalJournal of Functional Foods
Volume15
DOIs
Publication statusPublished - May 1 2015

Fingerprint

hyperglycemia
growth factors
fibroblasts
Cultured Cells
Intercellular Signaling Peptides and Proteins
cytokines
pomegranates
Cytokines
Cardiac Myocytes
Hyperglycemia
blackberries
dietary exposure
cardiomyopathy
raspberries
walnuts
diabetes mellitus
Fibroblasts
biotransformation
Chemokine CX3CL1
Diabetic Cardiomyopathies

Keywords

  • Ellagitannin colonic metabolites
  • Hyperglycaemia
  • Inflammation
  • Neonatal cardiac fibroblasts
  • Neonatal cardiomyocytes
  • Peripheral metabolism

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions. / Sala, Roberto; Mena, Pedro; Savi, Monia; Brighenti, Furio; Crozier, Alan; Miragoli, Michele; Stilli, Donatella; Del Rio, Daniele.

In: Journal of Functional Foods, Vol. 15, 01.05.2015, p. 97-105.

Research output: Contribution to journalArticle

Sala, Roberto ; Mena, Pedro ; Savi, Monia ; Brighenti, Furio ; Crozier, Alan ; Miragoli, Michele ; Stilli, Donatella ; Del Rio, Daniele. / Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions. In: Journal of Functional Foods. 2015 ; Vol. 15. pp. 97-105.
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