Urothelial carcinoma at the uretero-enteric junction: Multi-center evaluation of oncologic outcomes after radical nephroureterectomy

Ramy F. Youssef, Shahrokh F. Shariat, Yair Lotan, Nicholas Cost, Christopher G. Wood, Arthur I. Sagalowsky, Richard Zigeuner, Cord Langner, Thomas F. Chromecki, Francesco Montorsi, Christian Bolenz, Vitaly Margulis

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The natural history of urothelial carcinoma arising at the uretero-enteric junction (UEJ) is poorly defined, and the data guiding clinical management of these patients is limited. Therefore, we evaluated oncologic outcomes of patients treated for urothelial carcinoma at the UEJ. Methods: Utilizing a multi-institutional database of patients treated with radical nephroureterectomy (RNU), we assessed the clinicopathologic parameters and oncologic outcomes of UEJ tumors compared with other upper tract urothelial carcinomas (UTUC). Survival analyses were performed to determine independent predictors of disease recurrence and cancer-specific mortality after RNU. Results: The study included 1,363 patients, 921 men and 442 women with 36 months median follow-up after RNU. Compared with UTUC in the kidney or ureter, UEJ tumors (n = 22) were more likely to demonstrate features of advanced disease, which were proved to be independent predictors of disease recurrence and cancer-specific mortality after RNU. The 5 year disease-free survival (DFS) and cancer-specific survival (CSS) rates were 25% and 39% in those with UEJ tumors vs. 69% and 73% in those with UTUC in the kidney or ureter (P = 0.001 and P = 0.008, respectively). Conclusions: UEJ tumors harbor features of locally advanced disease associated with high risk of systemic recurrence and death from cancer after RNU. Our findings suggest the need for integration of systemic therapy into the management paradigm of these patients.

Original languageEnglish
Pages (from-to)676-681
Number of pages6
JournalUrologic Oncology: Seminars and Original Investigations
Volume31
Issue number5
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Prognosis
  • UEJ
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Oncology
  • Urology

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