US and MR imaging of peripheral nerves in leprosy

Carlo Martinoli, Lorenzo E. Derchi, Michele Bertolotto, Nicola Gandolfo, Stefano Bianchi, Paolo Fiallo, Enrico Nunzi

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Objective. To analyze peripheral nerves with ultrasonography (US) and magnetic resonance imaging (MR) in leprosy and assess the role of imaging in leprosy patients. Design and patients. Fifty-eight nerves with abnormal clinical features or electromyograms were examined in 23 leprosy patients by means of gray-scale US, Doppler US and MR imaging. Image analysis included: measurement of nerve cross-sectional area; assessment of nerve structure and MR signal intensities; identification of nerve compression within osteofibrous tunnels; detection of endoneural color flow signals and Gd-DTPA enhancement. Correlations were made with clinical findings and a control group of 20 subjects. Fourteen nerves in active reversal reaction were followed up after therapy. Results. Leprosy nerves were classified into three groups based on imaging appearance: group I consisted of 17 normal-appearing nerves; group II, of 30 enlarged nerves with fascicular abnormalities; group III, of 11 nerves with absent fascicular structure. Group II nerves were from patients subjected to reversal reactions; 75% of patients with group III nerves had a history of erythema nodosum leprosum. Nerve compression in osteofibrous tunnels was identified in 33% of group II and 18% of group III nerves. Doppler US and MR imaging were 74% and 92% sensitive in identifying active reactions, based on detection of endoneural color flow signals, long T2 and Gd enhancement. In 64% of cases, follow-up studies showed decreased color flow and Gd uptake after steroids and decompressive surgery. Conclusions. US and MR imaging are able to detect nerves abnormalities in leprosy. Active reversal reactions are indicated by endoneural color flow signals as well as by an increased T2 signal and Gd enhancement. These signs would suggest rapid progression of nerve damage and a poor prognosis unless antireactional treatment is started.

Original languageEnglish
Pages (from-to)142-150
Number of pages9
JournalSkeletal Radiology
Volume29
Issue number3
Publication statusPublished - Mar 2000

Fingerprint

Leprosy
Peripheral Nerves
Ultrasonography
Oculomotor Nerve
Magnetic Resonance Imaging
Color
Doppler Ultrasonography
Erythema Nodosum
Gadolinium DTPA
Electromyography
Steroids
Control Groups
Therapeutics

Keywords

  • Leprosy
  • MR imaging
  • Peripheral nerves
  • Ultrasonography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Martinoli, C., Derchi, L. E., Bertolotto, M., Gandolfo, N., Bianchi, S., Fiallo, P., & Nunzi, E. (2000). US and MR imaging of peripheral nerves in leprosy. Skeletal Radiology, 29(3), 142-150.

US and MR imaging of peripheral nerves in leprosy. / Martinoli, Carlo; Derchi, Lorenzo E.; Bertolotto, Michele; Gandolfo, Nicola; Bianchi, Stefano; Fiallo, Paolo; Nunzi, Enrico.

In: Skeletal Radiology, Vol. 29, No. 3, 03.2000, p. 142-150.

Research output: Contribution to journalArticle

Martinoli, C, Derchi, LE, Bertolotto, M, Gandolfo, N, Bianchi, S, Fiallo, P & Nunzi, E 2000, 'US and MR imaging of peripheral nerves in leprosy', Skeletal Radiology, vol. 29, no. 3, pp. 142-150.
Martinoli C, Derchi LE, Bertolotto M, Gandolfo N, Bianchi S, Fiallo P et al. US and MR imaging of peripheral nerves in leprosy. Skeletal Radiology. 2000 Mar;29(3):142-150.
Martinoli, Carlo ; Derchi, Lorenzo E. ; Bertolotto, Michele ; Gandolfo, Nicola ; Bianchi, Stefano ; Fiallo, Paolo ; Nunzi, Enrico. / US and MR imaging of peripheral nerves in leprosy. In: Skeletal Radiology. 2000 ; Vol. 29, No. 3. pp. 142-150.
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abstract = "Objective. To analyze peripheral nerves with ultrasonography (US) and magnetic resonance imaging (MR) in leprosy and assess the role of imaging in leprosy patients. Design and patients. Fifty-eight nerves with abnormal clinical features or electromyograms were examined in 23 leprosy patients by means of gray-scale US, Doppler US and MR imaging. Image analysis included: measurement of nerve cross-sectional area; assessment of nerve structure and MR signal intensities; identification of nerve compression within osteofibrous tunnels; detection of endoneural color flow signals and Gd-DTPA enhancement. Correlations were made with clinical findings and a control group of 20 subjects. Fourteen nerves in active reversal reaction were followed up after therapy. Results. Leprosy nerves were classified into three groups based on imaging appearance: group I consisted of 17 normal-appearing nerves; group II, of 30 enlarged nerves with fascicular abnormalities; group III, of 11 nerves with absent fascicular structure. Group II nerves were from patients subjected to reversal reactions; 75{\%} of patients with group III nerves had a history of erythema nodosum leprosum. Nerve compression in osteofibrous tunnels was identified in 33{\%} of group II and 18{\%} of group III nerves. Doppler US and MR imaging were 74{\%} and 92{\%} sensitive in identifying active reactions, based on detection of endoneural color flow signals, long T2 and Gd enhancement. In 64{\%} of cases, follow-up studies showed decreased color flow and Gd uptake after steroids and decompressive surgery. Conclusions. US and MR imaging are able to detect nerves abnormalities in leprosy. Active reversal reactions are indicated by endoneural color flow signals as well as by an increased T2 signal and Gd enhancement. These signs would suggest rapid progression of nerve damage and a poor prognosis unless antireactional treatment is started.",
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AU - Martinoli, Carlo

AU - Derchi, Lorenzo E.

AU - Bertolotto, Michele

AU - Gandolfo, Nicola

AU - Bianchi, Stefano

AU - Fiallo, Paolo

AU - Nunzi, Enrico

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N2 - Objective. To analyze peripheral nerves with ultrasonography (US) and magnetic resonance imaging (MR) in leprosy and assess the role of imaging in leprosy patients. Design and patients. Fifty-eight nerves with abnormal clinical features or electromyograms were examined in 23 leprosy patients by means of gray-scale US, Doppler US and MR imaging. Image analysis included: measurement of nerve cross-sectional area; assessment of nerve structure and MR signal intensities; identification of nerve compression within osteofibrous tunnels; detection of endoneural color flow signals and Gd-DTPA enhancement. Correlations were made with clinical findings and a control group of 20 subjects. Fourteen nerves in active reversal reaction were followed up after therapy. Results. Leprosy nerves were classified into three groups based on imaging appearance: group I consisted of 17 normal-appearing nerves; group II, of 30 enlarged nerves with fascicular abnormalities; group III, of 11 nerves with absent fascicular structure. Group II nerves were from patients subjected to reversal reactions; 75% of patients with group III nerves had a history of erythema nodosum leprosum. Nerve compression in osteofibrous tunnels was identified in 33% of group II and 18% of group III nerves. Doppler US and MR imaging were 74% and 92% sensitive in identifying active reactions, based on detection of endoneural color flow signals, long T2 and Gd enhancement. In 64% of cases, follow-up studies showed decreased color flow and Gd uptake after steroids and decompressive surgery. Conclusions. US and MR imaging are able to detect nerves abnormalities in leprosy. Active reversal reactions are indicated by endoneural color flow signals as well as by an increased T2 signal and Gd enhancement. These signs would suggest rapid progression of nerve damage and a poor prognosis unless antireactional treatment is started.

AB - Objective. To analyze peripheral nerves with ultrasonography (US) and magnetic resonance imaging (MR) in leprosy and assess the role of imaging in leprosy patients. Design and patients. Fifty-eight nerves with abnormal clinical features or electromyograms were examined in 23 leprosy patients by means of gray-scale US, Doppler US and MR imaging. Image analysis included: measurement of nerve cross-sectional area; assessment of nerve structure and MR signal intensities; identification of nerve compression within osteofibrous tunnels; detection of endoneural color flow signals and Gd-DTPA enhancement. Correlations were made with clinical findings and a control group of 20 subjects. Fourteen nerves in active reversal reaction were followed up after therapy. Results. Leprosy nerves were classified into three groups based on imaging appearance: group I consisted of 17 normal-appearing nerves; group II, of 30 enlarged nerves with fascicular abnormalities; group III, of 11 nerves with absent fascicular structure. Group II nerves were from patients subjected to reversal reactions; 75% of patients with group III nerves had a history of erythema nodosum leprosum. Nerve compression in osteofibrous tunnels was identified in 33% of group II and 18% of group III nerves. Doppler US and MR imaging were 74% and 92% sensitive in identifying active reactions, based on detection of endoneural color flow signals, long T2 and Gd enhancement. In 64% of cases, follow-up studies showed decreased color flow and Gd uptake after steroids and decompressive surgery. Conclusions. US and MR imaging are able to detect nerves abnormalities in leprosy. Active reversal reactions are indicated by endoneural color flow signals as well as by an increased T2 signal and Gd enhancement. These signs would suggest rapid progression of nerve damage and a poor prognosis unless antireactional treatment is started.

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