TY - JOUR
T1 - US-guided application of a new hybrid probe in human pancreatic adenocarcinoma
T2 - an ex vivo study
AU - Petrone, Maria Chiara
AU - Arcidiacono, Paolo Giorgio
AU - Carrara, Silvia
AU - Albarello, Luca
AU - Enderle, Markus D.
AU - Neugebauer, Alexander
AU - Boemo, Cinzia
AU - Doglioni, Claudio
AU - Testoni, Pier Alberto
PY - 2010
Y1 - 2010
N2 - Background: Ablative therapies such as radiofrequency and cryotechnology are widely used in oncological intervention but not in the pancreatic field because of their high operative risks. A new flexible bipolar ablation device (Cryotherm probe [CTP]) was developed combining radiofrequency and cryotechnology. Objective: To evaluate the efficacy of the CTP in destroying neoplastic tissue of explanted pancreatic tumors of patients with pancreatic adenocarcinoma. Design: Ex vivo clinical study. Setting: Inpatient hospital setting. Patients: This study involved 16 explanted pancreatic tumors from 16 patients. Interventions: CTP application was performed on explanted pancreatic tumors. Anatomic specimens were divided into 4 groups; each group received a predefined application time of 120 to 600 seconds. Main Outcome Measurements: The coagulation diameter (short axis) perpendicular to the device's longitudinal axis was used as the primary outcome measure. Results: All pancreatic specimens showed histological signs of coagulative necrosis. There was a positive correlation between the short axis of the obtained necrosis and duration of application (r = 0.74). Limitations: This study was an ex vivo study with all limitations typical of this kind of study. Conclusions: The CTP is effective in destroying neoplastic pancreatic tissue, creating an ablation zone, the extent of which is related to the duration of application.
AB - Background: Ablative therapies such as radiofrequency and cryotechnology are widely used in oncological intervention but not in the pancreatic field because of their high operative risks. A new flexible bipolar ablation device (Cryotherm probe [CTP]) was developed combining radiofrequency and cryotechnology. Objective: To evaluate the efficacy of the CTP in destroying neoplastic tissue of explanted pancreatic tumors of patients with pancreatic adenocarcinoma. Design: Ex vivo clinical study. Setting: Inpatient hospital setting. Patients: This study involved 16 explanted pancreatic tumors from 16 patients. Interventions: CTP application was performed on explanted pancreatic tumors. Anatomic specimens were divided into 4 groups; each group received a predefined application time of 120 to 600 seconds. Main Outcome Measurements: The coagulation diameter (short axis) perpendicular to the device's longitudinal axis was used as the primary outcome measure. Results: All pancreatic specimens showed histological signs of coagulative necrosis. There was a positive correlation between the short axis of the obtained necrosis and duration of application (r = 0.74). Limitations: This study was an ex vivo study with all limitations typical of this kind of study. Conclusions: The CTP is effective in destroying neoplastic pancreatic tissue, creating an ablation zone, the extent of which is related to the duration of application.
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U2 - 10.1016/j.gie.2010.02.014
DO - 10.1016/j.gie.2010.02.014
M3 - Article
C2 - 20598256
AN - SCOPUS:77952941263
VL - 71
SP - 1294
EP - 1297
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
SN - 0016-5107
IS - 7
ER -