US-Guided Percutaneous Radiofrequency Thermal Ablation for the Treatment of Solid Benign Hyperfunctioning or Compressive Thyroid Nodules

Maurilio Deandrea, Paolo Limone, Edoardo Basso, Alberto Mormile, Federico Ragazzoni, Elena Gamarra, Stefano Spiezia, Antongiulio Faggiano, Annamaria Colao, Filippo Molinari, Roberto Garberoglio

Research output: Contribution to journalArticle

Abstract

The aim of the study was to define the effectiveness and safety of ultrasound-guided percutaneous radiofrequency (RF) thermal ablation in the treatment of compressive solid benign thyroid nodules. Thirty-one patients not eligible for surgery or radioiodine (131I) treatment underwent RF ablation for benign nodules; a total of 33 nodules were treated (2 patients had 2 nodules treated in the same session): 10 cold nodules and 23 hyperfunctioning. Fourteen patients complained of compressive symptoms. Nodule volume, thyroid function and compressive symptoms were evaluated before treatment and at 1, 3 and 6 mo. Ultrasound-guided RF ablation was performed using a Starbust RITA® needle, with nine expandable prongs; total exposure time was 6 to 10 min at 95° C in one area or more of the nodule. Baseline volume (measured at the time of RF ablation) was 27.7 ± 21.5 mL (mean ± SD), but significantly decreased during follow-up: 19.2 ± 16.2 at 1 mo (-32.7%; p <0.001), 15.9 ± 14.1 mL at 3 mo (-46.4 %; p <0.001) and 14.6 ± 12.6 mL at 6 mo (-50.7%; p <0.001). After treatment, all patients with cold nodules remained euthyroid: five patients with hot nodules normalized thyroid function, and the remaining sixteen showed a partial remission of hyperthyroidism. Besides a sensation of heat and mild swelling of the neck, no major complications were observed. Improvement in compressive symptoms was reported by 13 patients, with a reduction on severity scale from 6.1 ± 1.4 to 2.2 ± 1.9 (p <0.0001). Radiofrequency was effective and safe in reducing volume by about 50% and compressive symptoms in large benign nodules. Hyperfunction was fully controlled in 24% of patients and partially reduced in the others. (E-mail: mdeandrea@libero.it).

Original languageEnglish
Pages (from-to)784-791
Number of pages8
JournalUltrasound in Medicine and Biology
Volume34
Issue number5
DOIs
Publication statusPublished - May 2008

Keywords

  • Radiofrequency
  • Thyroid nodules therapy
  • US-guided thermal ablation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Deandrea, M., Limone, P., Basso, E., Mormile, A., Ragazzoni, F., Gamarra, E., Spiezia, S., Faggiano, A., Colao, A., Molinari, F., & Garberoglio, R. (2008). US-Guided Percutaneous Radiofrequency Thermal Ablation for the Treatment of Solid Benign Hyperfunctioning or Compressive Thyroid Nodules. Ultrasound in Medicine and Biology, 34(5), 784-791. https://doi.org/10.1016/j.ultrasmedbio.2007.10.018