US-guided transcutaneous tru-cut biopsy of laryngo-hypopharyngeal lesions

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Abstract

Objective: To evaluate the feasibility and performance of ultrasound-guided transcutaneous tru-cut biopsy (USGTCB) in selected patients (with stenosis of airways or difficult intubation or contraindication to general anaesthesia) with untreated or previously treated suspicious laryngo-hypopharyngeal masses. Methods: Biopsies were performed with a free-hand technique by a single radiologist. Thirty-six USGTCBs were scheduled in 34 patients (24 males, 10 females; age range 47-95 years). Two USGTCBs were not performed, as lesions were not detectable: therefore, 16 USGTCBs were performed for an untreated mass suspicious for malignancy and 18 were performed for a mass suspicious for recurrence after radiotherapy alone, or associated with endoscopic laser surgery or chemotherapy. Results: USGTCB diagnosed 25 squamous cell carcinomas (73.5%) and nine benign lesions (26.5%); no false positives and two false negatives were reported, both in patients previously treated with radiotherapy. The sensitivity, specificity, positive and negative predictive value of the technique was 92.5%, 100%, 100% and 77.7% respectively, with no major complications. Conclusion: Although biopsy under microlaryngoscopy remains the "gold-standard" technique, USGTCB is feasible, carries the advantages of avoiding general anaesthesia, is suitable for outpatients and is cost-effective. If applied to selected patients, it could be considered for the histological diagnosis of both primary and recurrent laryngo-hypopharyngeal masses.

Original languageEnglish
Pages (from-to)1450-1455
Number of pages6
JournalEuropean Radiology
Volume20
Issue number6
DOIs
Publication statusPublished - 2010

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Biopsy
General Anesthesia
Radiotherapy
Laser Therapy
Intubation
Gold
Squamous Cell Carcinoma
Pathologic Constriction
Outpatients
Hand
Costs and Cost Analysis
Recurrence
Drug Therapy
Sensitivity and Specificity
Neoplasms

Keywords

  • Diagnosis
  • Histology
  • Laryngeal cancer
  • Tru-cut biopsy
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "US-guided transcutaneous tru-cut biopsy of laryngo-hypopharyngeal lesions",
abstract = "Objective: To evaluate the feasibility and performance of ultrasound-guided transcutaneous tru-cut biopsy (USGTCB) in selected patients (with stenosis of airways or difficult intubation or contraindication to general anaesthesia) with untreated or previously treated suspicious laryngo-hypopharyngeal masses. Methods: Biopsies were performed with a free-hand technique by a single radiologist. Thirty-six USGTCBs were scheduled in 34 patients (24 males, 10 females; age range 47-95 years). Two USGTCBs were not performed, as lesions were not detectable: therefore, 16 USGTCBs were performed for an untreated mass suspicious for malignancy and 18 were performed for a mass suspicious for recurrence after radiotherapy alone, or associated with endoscopic laser surgery or chemotherapy. Results: USGTCB diagnosed 25 squamous cell carcinomas (73.5{\%}) and nine benign lesions (26.5{\%}); no false positives and two false negatives were reported, both in patients previously treated with radiotherapy. The sensitivity, specificity, positive and negative predictive value of the technique was 92.5{\%}, 100{\%}, 100{\%} and 77.7{\%} respectively, with no major complications. Conclusion: Although biopsy under microlaryngoscopy remains the {"}gold-standard{"} technique, USGTCB is feasible, carries the advantages of avoiding general anaesthesia, is suitable for outpatients and is cost-effective. If applied to selected patients, it could be considered for the histological diagnosis of both primary and recurrent laryngo-hypopharyngeal masses.",
keywords = "Diagnosis, Histology, Laryngeal cancer, Tru-cut biopsy, Ultrasound",
author = "Lorenzo Preda and {De Fiori}, Elvio and Cristiano Rampinelli and Mohssen Ansarin and Giuseppe Petralia and Fausto Maffini and Daniela Alterio and Luke Bonello and Fausto Chiesa and Massimo Bellomi",
year = "2010",
doi = "10.1007/s00330-009-1682-1",
language = "English",
volume = "20",
pages = "1450--1455",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "6",

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TY - JOUR

T1 - US-guided transcutaneous tru-cut biopsy of laryngo-hypopharyngeal lesions

AU - Preda, Lorenzo

AU - De Fiori, Elvio

AU - Rampinelli, Cristiano

AU - Ansarin, Mohssen

AU - Petralia, Giuseppe

AU - Maffini, Fausto

AU - Alterio, Daniela

AU - Bonello, Luke

AU - Chiesa, Fausto

AU - Bellomi, Massimo

PY - 2010

Y1 - 2010

N2 - Objective: To evaluate the feasibility and performance of ultrasound-guided transcutaneous tru-cut biopsy (USGTCB) in selected patients (with stenosis of airways or difficult intubation or contraindication to general anaesthesia) with untreated or previously treated suspicious laryngo-hypopharyngeal masses. Methods: Biopsies were performed with a free-hand technique by a single radiologist. Thirty-six USGTCBs were scheduled in 34 patients (24 males, 10 females; age range 47-95 years). Two USGTCBs were not performed, as lesions were not detectable: therefore, 16 USGTCBs were performed for an untreated mass suspicious for malignancy and 18 were performed for a mass suspicious for recurrence after radiotherapy alone, or associated with endoscopic laser surgery or chemotherapy. Results: USGTCB diagnosed 25 squamous cell carcinomas (73.5%) and nine benign lesions (26.5%); no false positives and two false negatives were reported, both in patients previously treated with radiotherapy. The sensitivity, specificity, positive and negative predictive value of the technique was 92.5%, 100%, 100% and 77.7% respectively, with no major complications. Conclusion: Although biopsy under microlaryngoscopy remains the "gold-standard" technique, USGTCB is feasible, carries the advantages of avoiding general anaesthesia, is suitable for outpatients and is cost-effective. If applied to selected patients, it could be considered for the histological diagnosis of both primary and recurrent laryngo-hypopharyngeal masses.

AB - Objective: To evaluate the feasibility and performance of ultrasound-guided transcutaneous tru-cut biopsy (USGTCB) in selected patients (with stenosis of airways or difficult intubation or contraindication to general anaesthesia) with untreated or previously treated suspicious laryngo-hypopharyngeal masses. Methods: Biopsies were performed with a free-hand technique by a single radiologist. Thirty-six USGTCBs were scheduled in 34 patients (24 males, 10 females; age range 47-95 years). Two USGTCBs were not performed, as lesions were not detectable: therefore, 16 USGTCBs were performed for an untreated mass suspicious for malignancy and 18 were performed for a mass suspicious for recurrence after radiotherapy alone, or associated with endoscopic laser surgery or chemotherapy. Results: USGTCB diagnosed 25 squamous cell carcinomas (73.5%) and nine benign lesions (26.5%); no false positives and two false negatives were reported, both in patients previously treated with radiotherapy. The sensitivity, specificity, positive and negative predictive value of the technique was 92.5%, 100%, 100% and 77.7% respectively, with no major complications. Conclusion: Although biopsy under microlaryngoscopy remains the "gold-standard" technique, USGTCB is feasible, carries the advantages of avoiding general anaesthesia, is suitable for outpatients and is cost-effective. If applied to selected patients, it could be considered for the histological diagnosis of both primary and recurrent laryngo-hypopharyngeal masses.

KW - Diagnosis

KW - Histology

KW - Laryngeal cancer

KW - Tru-cut biopsy

KW - Ultrasound

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