Abstract
Objective: To evaluate the feasibility and performance of ultrasound-guided transcutaneous tru-cut biopsy (USGTCB) in selected patients (with stenosis of airways or difficult intubation or contraindication to general anaesthesia) with untreated or previously treated suspicious laryngo-hypopharyngeal masses. Methods: Biopsies were performed with a free-hand technique by a single radiologist. Thirty-six USGTCBs were scheduled in 34 patients (24 males, 10 females; age range 47-95 years). Two USGTCBs were not performed, as lesions were not detectable: therefore, 16 USGTCBs were performed for an untreated mass suspicious for malignancy and 18 were performed for a mass suspicious for recurrence after radiotherapy alone, or associated with endoscopic laser surgery or chemotherapy. Results: USGTCB diagnosed 25 squamous cell carcinomas (73.5%) and nine benign lesions (26.5%); no false positives and two false negatives were reported, both in patients previously treated with radiotherapy. The sensitivity, specificity, positive and negative predictive value of the technique was 92.5%, 100%, 100% and 77.7% respectively, with no major complications. Conclusion: Although biopsy under microlaryngoscopy remains the "gold-standard" technique, USGTCB is feasible, carries the advantages of avoiding general anaesthesia, is suitable for outpatients and is cost-effective. If applied to selected patients, it could be considered for the histological diagnosis of both primary and recurrent laryngo-hypopharyngeal masses.
| Original language | English |
|---|---|
| Pages (from-to) | 1450-1455 |
| Number of pages | 6 |
| Journal | European Radiology |
| Volume | 20 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2010 |
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Keywords
- Diagnosis
- Histology
- Laryngeal cancer
- Tru-cut biopsy
- Ultrasound
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
US-guided transcutaneous tru-cut biopsy of laryngo-hypopharyngeal lesions. / Preda, Lorenzo; De Fiori, Elvio; Rampinelli, Cristiano; Ansarin, Mohssen; Petralia, Giuseppe; Maffini, Fausto; Alterio, Daniela; Bonello, Luke; Chiesa, Fausto; Bellomi, Massimo.
In: European Radiology, Vol. 20, No. 6, 2010, p. 1450-1455.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - US-guided transcutaneous tru-cut biopsy of laryngo-hypopharyngeal lesions
AU - Preda, Lorenzo
AU - De Fiori, Elvio
AU - Rampinelli, Cristiano
AU - Ansarin, Mohssen
AU - Petralia, Giuseppe
AU - Maffini, Fausto
AU - Alterio, Daniela
AU - Bonello, Luke
AU - Chiesa, Fausto
AU - Bellomi, Massimo
PY - 2010
Y1 - 2010
N2 - Objective: To evaluate the feasibility and performance of ultrasound-guided transcutaneous tru-cut biopsy (USGTCB) in selected patients (with stenosis of airways or difficult intubation or contraindication to general anaesthesia) with untreated or previously treated suspicious laryngo-hypopharyngeal masses. Methods: Biopsies were performed with a free-hand technique by a single radiologist. Thirty-six USGTCBs were scheduled in 34 patients (24 males, 10 females; age range 47-95 years). Two USGTCBs were not performed, as lesions were not detectable: therefore, 16 USGTCBs were performed for an untreated mass suspicious for malignancy and 18 were performed for a mass suspicious for recurrence after radiotherapy alone, or associated with endoscopic laser surgery or chemotherapy. Results: USGTCB diagnosed 25 squamous cell carcinomas (73.5%) and nine benign lesions (26.5%); no false positives and two false negatives were reported, both in patients previously treated with radiotherapy. The sensitivity, specificity, positive and negative predictive value of the technique was 92.5%, 100%, 100% and 77.7% respectively, with no major complications. Conclusion: Although biopsy under microlaryngoscopy remains the "gold-standard" technique, USGTCB is feasible, carries the advantages of avoiding general anaesthesia, is suitable for outpatients and is cost-effective. If applied to selected patients, it could be considered for the histological diagnosis of both primary and recurrent laryngo-hypopharyngeal masses.
AB - Objective: To evaluate the feasibility and performance of ultrasound-guided transcutaneous tru-cut biopsy (USGTCB) in selected patients (with stenosis of airways or difficult intubation or contraindication to general anaesthesia) with untreated or previously treated suspicious laryngo-hypopharyngeal masses. Methods: Biopsies were performed with a free-hand technique by a single radiologist. Thirty-six USGTCBs were scheduled in 34 patients (24 males, 10 females; age range 47-95 years). Two USGTCBs were not performed, as lesions were not detectable: therefore, 16 USGTCBs were performed for an untreated mass suspicious for malignancy and 18 were performed for a mass suspicious for recurrence after radiotherapy alone, or associated with endoscopic laser surgery or chemotherapy. Results: USGTCB diagnosed 25 squamous cell carcinomas (73.5%) and nine benign lesions (26.5%); no false positives and two false negatives were reported, both in patients previously treated with radiotherapy. The sensitivity, specificity, positive and negative predictive value of the technique was 92.5%, 100%, 100% and 77.7% respectively, with no major complications. Conclusion: Although biopsy under microlaryngoscopy remains the "gold-standard" technique, USGTCB is feasible, carries the advantages of avoiding general anaesthesia, is suitable for outpatients and is cost-effective. If applied to selected patients, it could be considered for the histological diagnosis of both primary and recurrent laryngo-hypopharyngeal masses.
KW - Diagnosis
KW - Histology
KW - Laryngeal cancer
KW - Tru-cut biopsy
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=77952098488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952098488&partnerID=8YFLogxK
U2 - 10.1007/s00330-009-1682-1
DO - 10.1007/s00330-009-1682-1
M3 - Article
VL - 20
SP - 1450
EP - 1455
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 6
ER -