Use of a new mathematical model in fitting survivorship curves of Drosophila treated with the antioxidant thiazolidine carboxylic acid.

G. Rossolini, A. Basso, L. Piantanelli

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We have recently proposed a mathematical model of survival mortality kinetics. It is based on biological and statistical hypotheses and is able to fit survivorship curves even at advanced ages, where other models fail. The mathematical function contains two parameters, omega and So, related to deterministic and stochastic factors, respectively. In the present paper the model has been applied to a set of survival curves of Drosophila melanogaster. The different curves derived from populations of flies treated with different doses of the antioxidant thiazolidine carboxylic acid (TCA). The treatment induced a significant progressive increase of mean and maximum lifespan up to the TCA dietary concentration of 0.3%. Higher doses of TCA, on the contrary, were toxic, reducing both mean and maximum lifespan. An interpretation of the differential TCA effects has been attempted on the basis of the values assumed by the two model parameters.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume69
Issue number2
Publication statusPublished - Feb 1993

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Thiazolidines
Carboxylic Acids
Drosophila
Theoretical Models
Survival Rate
Antioxidants
Poisons
Statistical Models
Drosophila melanogaster
Diptera
Mortality
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "We have recently proposed a mathematical model of survival mortality kinetics. It is based on biological and statistical hypotheses and is able to fit survivorship curves even at advanced ages, where other models fail. The mathematical function contains two parameters, omega and So, related to deterministic and stochastic factors, respectively. In the present paper the model has been applied to a set of survival curves of Drosophila melanogaster. The different curves derived from populations of flies treated with different doses of the antioxidant thiazolidine carboxylic acid (TCA). The treatment induced a significant progressive increase of mean and maximum lifespan up to the TCA dietary concentration of 0.3{\%}. Higher doses of TCA, on the contrary, were toxic, reducing both mean and maximum lifespan. An interpretation of the differential TCA effects has been attempted on the basis of the values assumed by the two model parameters.",
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