Use of a rapid method for genotyping human platelet antigen systems in neonatal alloimmune thrombocytopenia

Laura Porretti, Silvia Lazzaroni, Paolo Rebulla, Francesca Poli, Mario Scalamogna, Girolamo Sirchia

Research output: Contribution to journalArticle

Abstract

We applied a polymerase chain reaction-sequence specific primer (PCR- SSP) method developed by other researchers to study 4 families of newborns with neonatal alloimmune thrombocytopenia (NAITP) in which serology had provided inconclusive human platelet antigen (HPA) typing data. This method allowed for the identification of the newborn HPAs which were incompatible with their respective mothers. They were HPA-2b, -1b, -3a, and -5b. This PCR- SSP is a useful tool for improving the ability to identify the incompatible HPA in NAITP.

Original languageEnglish
Pages (from-to)600-601
Number of pages2
JournalHaematologica
Volume82
Issue number5
Publication statusPublished - Sep 1997

Keywords

  • Genotyping
  • Neonatal alloimmune thrombocytopenia
  • Platelet antigens

ASJC Scopus subject areas

  • Hematology

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