Abstract
Medical treatment of reflux gastritis after partial gastrectomy is often unsatisfactory. Antacids containing aluminum hydroxide, as well as sucralfate, because of their reported capacity to bind bile acids and lysolecithin, may be useful in the treatment of reflux gastritis. Forty-five patients with reflux gastritis after gastrectomy were randomly treated with either antacids (Maalox® TC, 15 ml, QID), sucralfate (1 gm, TID), or placebo for eight weeks. The presence of dyspeptic symptoms and the grade of endoscopic and histologic changes were assessed before treatment and at the end of the study. Antacids were significantly better than placebo (P <0.01) in improving heartburn, nausea, and epigastric pain. Sucralfate was superior to placebo only in reducing heartburn (P = 0.03). Antacids were also significantly better than placebo in improving endoscopic features, but no changes were observed in histologic features in any group. In conclusion, antacids containing aluminum hydroxide may be an alternative treatment in patients with postgastrectomy reflux gastritis, and may even be useful in avoiding surgery.
| Original language | English |
|---|---|
| Pages (from-to) | 889-895 |
| Number of pages | 7 |
| Journal | Current Therapeutic Research |
| Volume | 48 |
| Issue number | 5 |
| Publication status | Published - 1990 |
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Use of antacids containing aluminum hydroxide compared with sucralfate and placebo in the treatment of postgastrectomy reflux gastritis. / Masci, E.; Bierti, L.; Tosi, T.; Testoni, P. A.; Bagnolo, F.; Tittobello, A.
In: Current Therapeutic Research, Vol. 48, No. 5, 1990, p. 889-895.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Use of antacids containing aluminum hydroxide compared with sucralfate and placebo in the treatment of postgastrectomy reflux gastritis
AU - Masci, E.
AU - Bierti, L.
AU - Tosi, T.
AU - Testoni, P. A.
AU - Bagnolo, F.
AU - Tittobello, A.
PY - 1990
Y1 - 1990
N2 - Medical treatment of reflux gastritis after partial gastrectomy is often unsatisfactory. Antacids containing aluminum hydroxide, as well as sucralfate, because of their reported capacity to bind bile acids and lysolecithin, may be useful in the treatment of reflux gastritis. Forty-five patients with reflux gastritis after gastrectomy were randomly treated with either antacids (Maalox® TC, 15 ml, QID), sucralfate (1 gm, TID), or placebo for eight weeks. The presence of dyspeptic symptoms and the grade of endoscopic and histologic changes were assessed before treatment and at the end of the study. Antacids were significantly better than placebo (P <0.01) in improving heartburn, nausea, and epigastric pain. Sucralfate was superior to placebo only in reducing heartburn (P = 0.03). Antacids were also significantly better than placebo in improving endoscopic features, but no changes were observed in histologic features in any group. In conclusion, antacids containing aluminum hydroxide may be an alternative treatment in patients with postgastrectomy reflux gastritis, and may even be useful in avoiding surgery.
AB - Medical treatment of reflux gastritis after partial gastrectomy is often unsatisfactory. Antacids containing aluminum hydroxide, as well as sucralfate, because of their reported capacity to bind bile acids and lysolecithin, may be useful in the treatment of reflux gastritis. Forty-five patients with reflux gastritis after gastrectomy were randomly treated with either antacids (Maalox® TC, 15 ml, QID), sucralfate (1 gm, TID), or placebo for eight weeks. The presence of dyspeptic symptoms and the grade of endoscopic and histologic changes were assessed before treatment and at the end of the study. Antacids were significantly better than placebo (P <0.01) in improving heartburn, nausea, and epigastric pain. Sucralfate was superior to placebo only in reducing heartburn (P = 0.03). Antacids were also significantly better than placebo in improving endoscopic features, but no changes were observed in histologic features in any group. In conclusion, antacids containing aluminum hydroxide may be an alternative treatment in patients with postgastrectomy reflux gastritis, and may even be useful in avoiding surgery.
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M3 - Article
VL - 48
SP - 889
EP - 895
JO - Current Therapeutic Research - Clinical and Experimental
JF - Current Therapeutic Research - Clinical and Experimental
SN - 0011-393X
IS - 5
ER -