Use of antacids containing aluminum hydroxide compared with sucralfate and placebo in the treatment of postgastrectomy reflux gastritis

E. Masci, L. Bierti, T. Tosi, P. A. Testoni, F. Bagnolo, A. Tittobello

Research output: Contribution to journalArticle

Abstract

Medical treatment of reflux gastritis after partial gastrectomy is often unsatisfactory. Antacids containing aluminum hydroxide, as well as sucralfate, because of their reported capacity to bind bile acids and lysolecithin, may be useful in the treatment of reflux gastritis. Forty-five patients with reflux gastritis after gastrectomy were randomly treated with either antacids (Maalox® TC, 15 ml, QID), sucralfate (1 gm, TID), or placebo for eight weeks. The presence of dyspeptic symptoms and the grade of endoscopic and histologic changes were assessed before treatment and at the end of the study. Antacids were significantly better than placebo (P <0.01) in improving heartburn, nausea, and epigastric pain. Sucralfate was superior to placebo only in reducing heartburn (P = 0.03). Antacids were also significantly better than placebo in improving endoscopic features, but no changes were observed in histologic features in any group. In conclusion, antacids containing aluminum hydroxide may be an alternative treatment in patients with postgastrectomy reflux gastritis, and may even be useful in avoiding surgery.

Original languageEnglish
Pages (from-to)889-895
Number of pages7
JournalCurrent Therapeutic Research
Volume48
Issue number5
Publication statusPublished - 1990

Fingerprint

Sucralfate
Aluminum Hydroxide
Antacids
Gastritis
Placebos
Heartburn
Gastrectomy
Therapeutics
Lysophosphatidylcholines
Bile Acids and Salts
Nausea
Pain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Use of antacids containing aluminum hydroxide compared with sucralfate and placebo in the treatment of postgastrectomy reflux gastritis. / Masci, E.; Bierti, L.; Tosi, T.; Testoni, P. A.; Bagnolo, F.; Tittobello, A.

In: Current Therapeutic Research, Vol. 48, No. 5, 1990, p. 889-895.

Research output: Contribution to journalArticle

@article{5eca644e1fba4f5f860a2d0e37e55ee4,
title = "Use of antacids containing aluminum hydroxide compared with sucralfate and placebo in the treatment of postgastrectomy reflux gastritis",
abstract = "Medical treatment of reflux gastritis after partial gastrectomy is often unsatisfactory. Antacids containing aluminum hydroxide, as well as sucralfate, because of their reported capacity to bind bile acids and lysolecithin, may be useful in the treatment of reflux gastritis. Forty-five patients with reflux gastritis after gastrectomy were randomly treated with either antacids (Maalox{\circledR} TC, 15 ml, QID), sucralfate (1 gm, TID), or placebo for eight weeks. The presence of dyspeptic symptoms and the grade of endoscopic and histologic changes were assessed before treatment and at the end of the study. Antacids were significantly better than placebo (P <0.01) in improving heartburn, nausea, and epigastric pain. Sucralfate was superior to placebo only in reducing heartburn (P = 0.03). Antacids were also significantly better than placebo in improving endoscopic features, but no changes were observed in histologic features in any group. In conclusion, antacids containing aluminum hydroxide may be an alternative treatment in patients with postgastrectomy reflux gastritis, and may even be useful in avoiding surgery.",
author = "E. Masci and L. Bierti and T. Tosi and Testoni, {P. A.} and F. Bagnolo and A. Tittobello",
year = "1990",
language = "English",
volume = "48",
pages = "889--895",
journal = "Current Therapeutic Research - Clinical and Experimental",
issn = "0011-393X",
publisher = "Excerpta Medica",
number = "5",

}

TY - JOUR

T1 - Use of antacids containing aluminum hydroxide compared with sucralfate and placebo in the treatment of postgastrectomy reflux gastritis

AU - Masci, E.

AU - Bierti, L.

AU - Tosi, T.

AU - Testoni, P. A.

AU - Bagnolo, F.

AU - Tittobello, A.

PY - 1990

Y1 - 1990

N2 - Medical treatment of reflux gastritis after partial gastrectomy is often unsatisfactory. Antacids containing aluminum hydroxide, as well as sucralfate, because of their reported capacity to bind bile acids and lysolecithin, may be useful in the treatment of reflux gastritis. Forty-five patients with reflux gastritis after gastrectomy were randomly treated with either antacids (Maalox® TC, 15 ml, QID), sucralfate (1 gm, TID), or placebo for eight weeks. The presence of dyspeptic symptoms and the grade of endoscopic and histologic changes were assessed before treatment and at the end of the study. Antacids were significantly better than placebo (P <0.01) in improving heartburn, nausea, and epigastric pain. Sucralfate was superior to placebo only in reducing heartburn (P = 0.03). Antacids were also significantly better than placebo in improving endoscopic features, but no changes were observed in histologic features in any group. In conclusion, antacids containing aluminum hydroxide may be an alternative treatment in patients with postgastrectomy reflux gastritis, and may even be useful in avoiding surgery.

AB - Medical treatment of reflux gastritis after partial gastrectomy is often unsatisfactory. Antacids containing aluminum hydroxide, as well as sucralfate, because of their reported capacity to bind bile acids and lysolecithin, may be useful in the treatment of reflux gastritis. Forty-five patients with reflux gastritis after gastrectomy were randomly treated with either antacids (Maalox® TC, 15 ml, QID), sucralfate (1 gm, TID), or placebo for eight weeks. The presence of dyspeptic symptoms and the grade of endoscopic and histologic changes were assessed before treatment and at the end of the study. Antacids were significantly better than placebo (P <0.01) in improving heartburn, nausea, and epigastric pain. Sucralfate was superior to placebo only in reducing heartburn (P = 0.03). Antacids were also significantly better than placebo in improving endoscopic features, but no changes were observed in histologic features in any group. In conclusion, antacids containing aluminum hydroxide may be an alternative treatment in patients with postgastrectomy reflux gastritis, and may even be useful in avoiding surgery.

UR - http://www.scopus.com/inward/record.url?scp=0025260004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025260004&partnerID=8YFLogxK

M3 - Article

VL - 48

SP - 889

EP - 895

JO - Current Therapeutic Research - Clinical and Experimental

JF - Current Therapeutic Research - Clinical and Experimental

SN - 0011-393X

IS - 5

ER -