Use of asenapine in clinical practice for the management of bipolar mania.

Allan H. Young, Alfredo Carlo Altamura, Ana M. González-Pinto, Bruno Millet, Klaus Wiedemann

Research output: Contribution to journalArticlepeer-review


Bipolar disorder is a chronic mental illness associated with high levels of somatic morbidity, comorbidity and mortality. Treatment guidelines for bipolar mania generally recommend initiating first-line therapy with a second-generation antipsychotic or mood stabiliser, either alone or in combination. Asenapine is a second-generation antipsychotic with a unique receptor binding profile, licensed for the treatment of manic episodes in adults with bipolar I disorder. 'Real-world' data are needed to complement evidence from clinical trials, in order to provide clinicians with pragmatic information regarding the likely risks and benefits of using a new agent in clinical practice. Evidence from real-world case reports demonstrates that - as in clinical trials - asenapine is effective in treating mania and mixed episodes associated with bipolar I disorder, whether used as monotherapy or in combination with a mood stabiliser. It has a rapid onset of antimanic effect and an early improvement is associated with treatment outcome. Asenapine also shows promise in controlling depressive symptoms and clinically challenging mixed states. Asenapine has a favourable tolerability profile, compared with other first-line agents, having a minimal impact on weight and metabolic parameters. Asenapine should be considered a first-line treatment option for adults with bipolar I disorder.

Original languageEnglish
Pages (from-to)3-13
Number of pages11
JournalJournal of Psychopharmacology
Issue number4 Suppl
Publication statusPublished - Apr 2013

ASJC Scopus subject areas

  • Medicine(all)

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