Use of bovine lactoferrin for Helicobacter pylori eradication

F. Di Mario, G. Aragona, N. Dal Bò, G. M. Cavestro, L. Cavallaro, V. Iori, G. Comparato, G. Leandro, A. Pilotto, A. Franzè

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Background. One-week triple therapy is the most frequently recommended treatment for Helicobacter pylori infection. Eradication rate is satisfactory, nevertheless is advisable to look for more effective therapies. Aim. To test the efficacy of a standard triple therapy plus bovine lactoferrin in the eradication of H. pylori infection. Patients and Methods. One hundred and fifty consecutive H. pylori positive patients, suffering from dyspeptic symptoms were recruited in a 7-day triple therapy open randomised single centre study with rabeprazole, clarithromycin, tinidazole, bovine lactoferrin (group A) or rabeprazole, clarithromycin, tinidazole (group B), or a 10-day therapy with rabeprazole, clarithromycin, tinidazole (group C). H. pylori status was assessed 8 weeks after the end of the treatment by means of a 13C-urea breath test or a H. pylori stool antigen-test. Results. Eradication rates (intention to treat/per protocol) were: group A (92.2/95.9%), group B (71.2/72.5%) and group C (70.2/75%). The efficacy of triple therapy added with lactoferrin was significantly higher than other two regimens (p=0.01, intention to treat analysis; p=0.005, per protocol analysis). Conclusion. These results suggest that lactoferrin tested in the present study was effective in curing H. pylori and could be a new agent to assist the antimicrobials in the eradication of the bacterium.

Original languageEnglish
Pages (from-to)706-710
Number of pages5
JournalDigestive and Liver Disease
Volume35
Issue number10
DOIs
Publication statusPublished - Oct 2003

Fingerprint

Lactoferrin
Helicobacter pylori
Rabeprazole
Tinidazole
Clarithromycin
Helicobacter Infections
Therapeutics
Intention to Treat Analysis
Breath Tests
Urea
Bacteria
Antigens

Keywords

  • Bovine lactoferrin
  • Eradication
  • Helicobacter

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Di Mario, F., Aragona, G., Dal Bò, N., Cavestro, G. M., Cavallaro, L., Iori, V., ... Franzè, A. (2003). Use of bovine lactoferrin for Helicobacter pylori eradication. Digestive and Liver Disease, 35(10), 706-710. https://doi.org/10.1016/S1590-8658(03)00409-2

Use of bovine lactoferrin for Helicobacter pylori eradication. / Di Mario, F.; Aragona, G.; Dal Bò, N.; Cavestro, G. M.; Cavallaro, L.; Iori, V.; Comparato, G.; Leandro, G.; Pilotto, A.; Franzè, A.

In: Digestive and Liver Disease, Vol. 35, No. 10, 10.2003, p. 706-710.

Research output: Contribution to journalArticle

Di Mario, F, Aragona, G, Dal Bò, N, Cavestro, GM, Cavallaro, L, Iori, V, Comparato, G, Leandro, G, Pilotto, A & Franzè, A 2003, 'Use of bovine lactoferrin for Helicobacter pylori eradication', Digestive and Liver Disease, vol. 35, no. 10, pp. 706-710. https://doi.org/10.1016/S1590-8658(03)00409-2
Di Mario, F. ; Aragona, G. ; Dal Bò, N. ; Cavestro, G. M. ; Cavallaro, L. ; Iori, V. ; Comparato, G. ; Leandro, G. ; Pilotto, A. ; Franzè, A. / Use of bovine lactoferrin for Helicobacter pylori eradication. In: Digestive and Liver Disease. 2003 ; Vol. 35, No. 10. pp. 706-710.
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AU - Dal Bò, N.

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AU - Cavallaro, L.

AU - Iori, V.

AU - Comparato, G.

AU - Leandro, G.

AU - Pilotto, A.

AU - Franzè, A.

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AB - Background. One-week triple therapy is the most frequently recommended treatment for Helicobacter pylori infection. Eradication rate is satisfactory, nevertheless is advisable to look for more effective therapies. Aim. To test the efficacy of a standard triple therapy plus bovine lactoferrin in the eradication of H. pylori infection. Patients and Methods. One hundred and fifty consecutive H. pylori positive patients, suffering from dyspeptic symptoms were recruited in a 7-day triple therapy open randomised single centre study with rabeprazole, clarithromycin, tinidazole, bovine lactoferrin (group A) or rabeprazole, clarithromycin, tinidazole (group B), or a 10-day therapy with rabeprazole, clarithromycin, tinidazole (group C). H. pylori status was assessed 8 weeks after the end of the treatment by means of a 13C-urea breath test or a H. pylori stool antigen-test. Results. Eradication rates (intention to treat/per protocol) were: group A (92.2/95.9%), group B (71.2/72.5%) and group C (70.2/75%). The efficacy of triple therapy added with lactoferrin was significantly higher than other two regimens (p=0.01, intention to treat analysis; p=0.005, per protocol analysis). Conclusion. These results suggest that lactoferrin tested in the present study was effective in curing H. pylori and could be a new agent to assist the antimicrobials in the eradication of the bacterium.

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