Use of bovine lactoferrin for Helicobacter pylori eradication

F. Di Mario, G. Aragona, N. Dal Bò, G. M. Cavestro, L. Cavallaro, V. Iori, G. Comparato, G. Leandro, A. Pilotto, A. Franzè

Research output: Contribution to journalArticle


Background. One-week triple therapy is the most frequently recommended treatment for Helicobacter pylori infection. Eradication rate is satisfactory, nevertheless is advisable to look for more effective therapies. Aim. To test the efficacy of a standard triple therapy plus bovine lactoferrin in the eradication of H. pylori infection. Patients and Methods. One hundred and fifty consecutive H. pylori positive patients, suffering from dyspeptic symptoms were recruited in a 7-day triple therapy open randomised single centre study with rabeprazole, clarithromycin, tinidazole, bovine lactoferrin (group A) or rabeprazole, clarithromycin, tinidazole (group B), or a 10-day therapy with rabeprazole, clarithromycin, tinidazole (group C). H. pylori status was assessed 8 weeks after the end of the treatment by means of a 13C-urea breath test or a H. pylori stool antigen-test. Results. Eradication rates (intention to treat/per protocol) were: group A (92.2/95.9%), group B (71.2/72.5%) and group C (70.2/75%). The efficacy of triple therapy added with lactoferrin was significantly higher than other two regimens (p=0.01, intention to treat analysis; p=0.005, per protocol analysis). Conclusion. These results suggest that lactoferrin tested in the present study was effective in curing H. pylori and could be a new agent to assist the antimicrobials in the eradication of the bacterium.

Original languageEnglish
Pages (from-to)706-710
Number of pages5
JournalDigestive and Liver Disease
Issue number10
Publication statusPublished - Oct 2003


  • Bovine lactoferrin
  • Eradication
  • Helicobacter

ASJC Scopus subject areas

  • Gastroenterology

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