Use of continuous cell lines for studying tumor heterogeneity and drug resistance

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Abstract

Intratumoral heterogeneity was observed in two tumor lines (SbC 11 and SbC 12) derived from a single biopsy of a melanoma patient. Differences in drug sensitivity were observed in three cell lines of small cell lung carcinoma derived from the same patient, before (AE1), and after (AE2 and AE3) therapy with Adriamycin (ADM) and Cisplatinum (DDP). Moreover, heterogeneity in biological features and in drug sensitivity was observed in three continuous human glioma derived cell lines (LI, DF., and DP). The results show the importance of continuous cell lines for studying tumor heterogeneity and evaluating the effectiveness of antineoplastic agents.

Original languageEnglish
Pages (from-to)298-302
Number of pages5
JournalMedicina - Rivista della Enciclopedia Medica Italiana
Volume10
Issue number3
Publication statusPublished - 1990

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Tumor Cell Line
Drug Resistance
Cell Line
Small Cell Lung Carcinoma
Glioma
Pharmaceutical Preparations
Antineoplastic Agents
Doxorubicin
Melanoma
Biopsy
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Use of continuous cell lines for studying tumor heterogeneity and drug resistance",
abstract = "Intratumoral heterogeneity was observed in two tumor lines (SbC 11 and SbC 12) derived from a single biopsy of a melanoma patient. Differences in drug sensitivity were observed in three cell lines of small cell lung carcinoma derived from the same patient, before (AE1), and after (AE2 and AE3) therapy with Adriamycin (ADM) and Cisplatinum (DDP). Moreover, heterogeneity in biological features and in drug sensitivity was observed in three continuous human glioma derived cell lines (LI, DF., and DP). The results show the importance of continuous cell lines for studying tumor heterogeneity and evaluating the effectiveness of antineoplastic agents.",
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T1 - Use of continuous cell lines for studying tumor heterogeneity and drug resistance

AU - Del Bufalo, D.

AU - Cucco, C.

AU - Leonetti, C.

PY - 1990

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N2 - Intratumoral heterogeneity was observed in two tumor lines (SbC 11 and SbC 12) derived from a single biopsy of a melanoma patient. Differences in drug sensitivity were observed in three cell lines of small cell lung carcinoma derived from the same patient, before (AE1), and after (AE2 and AE3) therapy with Adriamycin (ADM) and Cisplatinum (DDP). Moreover, heterogeneity in biological features and in drug sensitivity was observed in three continuous human glioma derived cell lines (LI, DF., and DP). The results show the importance of continuous cell lines for studying tumor heterogeneity and evaluating the effectiveness of antineoplastic agents.

AB - Intratumoral heterogeneity was observed in two tumor lines (SbC 11 and SbC 12) derived from a single biopsy of a melanoma patient. Differences in drug sensitivity were observed in three cell lines of small cell lung carcinoma derived from the same patient, before (AE1), and after (AE2 and AE3) therapy with Adriamycin (ADM) and Cisplatinum (DDP). Moreover, heterogeneity in biological features and in drug sensitivity was observed in three continuous human glioma derived cell lines (LI, DF., and DP). The results show the importance of continuous cell lines for studying tumor heterogeneity and evaluating the effectiveness of antineoplastic agents.

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