Use of different time-domain techniques for metabolite maps reconstruction in 1H-MRSI

M. Sansone, M. Cesarelli, P. Bifulco, M. Bracale, G. Tedeschi, S. Bonavita, F. Di Salle

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

1H-MRSI can provide in vivo information about specific metabolites in biological tissues. Main applications of this technique concern brain studies. However, routine clinical applications are still limited by a variety of factors such as the long acquisition time, the poor spatial resolution, the presence of undesired signals coming from water and fat, the difficulties in data-processing. These problems can be addressed with two different approaches: the design of new excitation pulses sequences, and the improvement of data-processing techniques. In this preliminary study the latter approach has been adopted. Echoes are acquired without any suppression pulses sequence: the undesired signal coming from water is attenuated by means of an opportune processing, using a filtering technique based on SVD. A specific algorithm for peaks detection based upon iterative fitting (VARPRO) was developed. Maps relative to the four main metabolites in the brain are reconstructed and presented.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
EditorsJ.D. Enderle
Pages2002-2003
Number of pages2
Volume3
Publication statusPublished - 2000
Event22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Chicago, IL, United States
Duration: Jul 23 2000Jul 28 2000

Other

Other22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CountryUnited States
CityChicago, IL
Period7/23/007/28/00

Keywords

  • MRSI
  • SVD
  • Time-domain analysis
  • VARPRO

ASJC Scopus subject areas

  • Bioengineering

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