Use of DPB1 T-cell epitope algorithm among italian transplant centers: A survey on behalf of Associazione Italiana di Immunogenetica e Biologia dei Trapianti

Roberto Crocchiolo, Lia Mele, Manuela Testi, Mariadele Scollo Chiara, Barbara Murgia, Angela Rossi, Cinzia Vecchiato, Paola Grammatico, Donata Mininni, Elena Longhi, Silvia Manfroi, Silvia Giuliodori, Laura Castellani, Graziella Carella, Sara Lai, Pia Azzaro Maria, Benedetta Mazzi, Laura Perotti, Roberta Penta, Claudia LombardoRita Tognellini, Marco Andreani, Paola Albergoni Maria, Sonia Nesci, Valentina Cappuzzo, Patrizia Chiusolo, Elena Garino, Giuseppe Cappucci, Nadia Ceschini, Elena Bevilacqua, Elisabetta Guizzardi, Marina Tagliaferri Cinzia, Antonina Piazza, Carlo Carcassi, Valeria Miotti

Research output: Contribution to journalArticlepeer-review

Abstract

The HLA-DPB1 locus has been demonstrated to have a significant role on patients' outcome after allogeneic HSCT, and the so-called T-cell epitope (TCE) algorithm has been incorporated in international guidelines for the selection of unrelated donors. The purpose of the present study is to measure, through a national survey conducted on behalf of the Associazione Italiana di Immunogenetica e Biologia dei Trapianti (AIBT), the extent of awareness and use of HLA-DPB1 TCE-based algorithms during the donor search. 89% of the HLA laboratories answered to a short questionnaire and the results showed a progressive increase of the laboratories typing DPB1 in patients and their potential donors during the search (from 44% to 79% during the 2010–2019 period) as well as the application of a TCE-based algorithm for the donor choice whenever possible (from 24% to 65% during the same period). The DP-permissiveness status is detailed in the official HLA typing report by 12%, 32% and 50% of laboratories in 2010, 2015 and 2019, respectively. The present data indicate an encouraging raise in the awareness of the HLA-DPB1 role in unrelated donor selection; noteworthy, mentioning the TCE-based permissiveness status in the HLA typing report of each potential unrelated donor represents a notable mean to raise awareness among transplant physicians and to support them in their task of choosing the best donor. Nonetheless, despite the compelling evidence of the predictive ability of TCE-based algorithms, further efforts are still needed to extend its application to all transplant centers in Italy.

Original languageEnglish
Pages (from-to)114-121
Number of pages8
JournalHLA
Volume98
Issue number2
DOIs
Publication statusPublished - Aug 2021

Keywords

  • donor
  • hematopoietic stem cell transplantation
  • HLA-DPB1
  • T-cell epitope algorithm

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Genetics

Fingerprint

Dive into the research topics of 'Use of DPB1 T-cell epitope algorithm among italian transplant centers: A survey on behalf of Associazione Italiana di Immunogenetica e Biologia dei Trapianti'. Together they form a unique fingerprint.

Cite this