Use of enteroscopy for the detection of malignant and premalignant lesions of the small bowel in complicated celiac disease: a meta-analysis

Luca Elli, Giovanni Casazza, Martina Locatelli, Federica Branchi, Francesca Ferretti, Dario Conte, Mirella Fraquelli

Research output: Contribution to journalReview article

Abstract

Background and Aims Enteroscopy (wireless or wired) is the reference standard for small-bowel (SB) diseases, and it has been applied to detect SB malignancies in complicated celiac disease (CD) with heterogeneous results. The aim of this meta-analysis was to obtain a diagnostic yield (DY) by pooling the data of studies that investigated the use of enteroscopy to detect SB adverse events in CD. Methods We performed an online search for studies estimating the DY of wireless and wired enteroscopy in predicting the presence of SB premalignant and/or malignant lesions. The DerSimonian and Laird random-effects method was used to pool the arcsine-transformed proportions of patients with the events. Three meta-analyses were performed considering the following events: the presence of a malignancy, premalignant damage (ulcerative jejunoileitis [UJ]), or the presence of a malignancy or UJ. A subgroup analysis was performed after extracting (if possible) patients with refractory CD (RCD). Results Of the 529 titles initially resulting from the search, 10 studies on capsule enteroscopy (CE) and 3 on double-balloon or push enteroscopy met the inclusion criteria. Overall, 439 and 76 patients were enrolled in these studies using CE and enteroscopy, respectively. Twelve tumors and 47 UJs were found by CE versus 8 tumors and 13 UJs detected by wired enteroscopy. For malignancies the CE yield was 1.9% (95% CI,.5%-3.8%) and wired enteroscopy yield 8.7% (95% CI, 0%-21.2%); similarly, for UJ the DYs were 8.4% (95% CI, 2.1%-17.7%) and 16.7% (95% CI, 8.7%-26.3%); for either UJ or neoplasia the DYs were 13.0% (95% CI, 5.6%-22.5%) and 27.7% (95% CI, 14.8%-42.6%). For RCD the DYs of all enteroscopic techniques were 1.8% (95% CI, 0%-7.7%) for neoplasia, 22.3% (95% CI, 8.2%-39.7%) for UJ, and 27.5% (95% CI, 13.1%-44.2%) for either. Conclusions Enteroscopy is a powerful and efficient diagnostic tool for the detection of SB malignancies in complicated CD.

Original languageEnglish
Pages (from-to)264-273.e1
JournalGastrointestinal Endoscopy
Volume86
Issue number2
DOIs
Publication statusPublished - Aug 1 2017

Keywords

  • capsule enteroscopy
  • CD
  • CE
  • celiac disease
  • DAE
  • DBE
  • device-assisted enteroscopy
  • diagnostic yield
  • double-balloon enteroscopy
  • DY
  • EATL
  • enteropathy-associated T-cell lymphoma
  • GFD
  • gluten free diet
  • RCD
  • refractory celiac disease
  • SB
  • small bowel
  • T-cell receptor
  • TCR
  • UJ
  • ulcerative jejunoileitis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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