The administration of erythromycin was previously reported to increase the blood level of carbamazepine (CBZ), resulting in unexpected and severe intoxication in children with epilepsy [1-3]. The mechanism of this interaction is presumed to be inhibition of the P450 enzyme system, producing decreased CBZ clearance when the two medications are given together . We have used this effect to achieve therapeutic levels of CBZ in young children affected by symptomatic drug-resistant partial seizures, in whom we were unable to obtain adequate levels despite a dose increase because of individual metabolism.
|Number of pages||1|
|Journal||Brain and Development|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health