Use of estrogen antagonists and aromatase inhibitors in endometriosis

Paola Viganò, Silvia Mangioni, Maria Paola Odorizzi, Annalisa Chiodini, Sabrina Rocca, Ilda Chiodo

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Endometriosis is an estrogen-dependent disorder mostly occurring in reproductive-age women. Various therapies have been used in an attempt to treat endometriosis, including ovarian suppression therapy, surgical treatment or a combination of these strategies. However, in general, substantial surgery remains the primary treatment option for endometriosis at all stages. Recently, aromatase inhibitors and anti-estrogens have been proposed as novel potential candidates. The rationale for the use of aromatase inhibitors is mostly related to the high aromatase expression in endometriotic cysts and extra-ovarian endometriotic implants. Among anti-estrogens, raloxifene has been investigated in animal models with good results, but in premenopausal women, the compound does not seem to suppress estrogen production.

Original languageEnglish
Pages (from-to)1209-1212
Number of pages4
JournalCurrent Opinion in Investigational Drugs
Volume4
Issue number10
Publication statusPublished - Oct 2003

Fingerprint

Estrogen Antagonists
Aromatase Inhibitors
Endometriosis
Estrogens
Ovarian Cysts
Aromatase
Therapeutics
Animal Models

Keywords

  • Anti-estrogens
  • Aromatase inhibitors
  • Endometriosis
  • Estrogen antagonists
  • Letrozole
  • Raloxifene
  • SERM

ASJC Scopus subject areas

  • Pharmacology

Cite this

Viganò, P., Mangioni, S., Odorizzi, M. P., Chiodini, A., Rocca, S., & Chiodo, I. (2003). Use of estrogen antagonists and aromatase inhibitors in endometriosis. Current Opinion in Investigational Drugs, 4(10), 1209-1212.

Use of estrogen antagonists and aromatase inhibitors in endometriosis. / Viganò, Paola; Mangioni, Silvia; Odorizzi, Maria Paola; Chiodini, Annalisa; Rocca, Sabrina; Chiodo, Ilda.

In: Current Opinion in Investigational Drugs, Vol. 4, No. 10, 10.2003, p. 1209-1212.

Research output: Contribution to journalArticle

Viganò, P, Mangioni, S, Odorizzi, MP, Chiodini, A, Rocca, S & Chiodo, I 2003, 'Use of estrogen antagonists and aromatase inhibitors in endometriosis', Current Opinion in Investigational Drugs, vol. 4, no. 10, pp. 1209-1212.
Viganò P, Mangioni S, Odorizzi MP, Chiodini A, Rocca S, Chiodo I. Use of estrogen antagonists and aromatase inhibitors in endometriosis. Current Opinion in Investigational Drugs. 2003 Oct;4(10):1209-1212.
Viganò, Paola ; Mangioni, Silvia ; Odorizzi, Maria Paola ; Chiodini, Annalisa ; Rocca, Sabrina ; Chiodo, Ilda. / Use of estrogen antagonists and aromatase inhibitors in endometriosis. In: Current Opinion in Investigational Drugs. 2003 ; Vol. 4, No. 10. pp. 1209-1212.
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