Use of fertility drugs and risk of ovarian cancer

Fabio Parazzini, Claudio Pelucchi, Eva Negri, Silvia Franceschi, Renato Talamini, Maurizio Montella, Carlo La Vecchia

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: The potential association between fertility drugs and risk of ovarian cancer has been analysed using data from a case-control study conducted between January 1992 and September 1999 in four Italian areas. Methods: Cases were 1031 women (median age 56, range 18-79 years) with incident, histologically confirmed epithelial ovarian cancer. Controls were 2411 women (median age 57, range 17-79 years) residing in the same geographical areas and admitted to the same network of hospitals for cases for a wide spectrum of acute, non neoplastic, non hormone-related conditions. Results: A total of 15 cases and 26 controls reported use of fertility drugs. The corresponding odds ratio (OR) was 1.3 (95% confidence interval 0.7-2.5). The OR was 1.2 for women reporting last use 25 years. Conclusions: Considering calendar year at use, the OR was non-significantly above unity for women reporting fertility drug use after 1970. The OR was 0.6 among nulliparous women and 1.9 among parous ones.

Original languageEnglish
Pages (from-to)1372-1375
Number of pages4
JournalHuman Reproduction
Volume16
Issue number7
Publication statusPublished - 2001

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Fertility Agents
Ovarian Neoplasms
Odds Ratio
Case-Control Studies
Hormones
Confidence Intervals

Keywords

  • Fertility drugs
  • Gonadotrophins
  • Ovarian cancer

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Parazzini, F., Pelucchi, C., Negri, E., Franceschi, S., Talamini, R., Montella, M., & La Vecchia, C. (2001). Use of fertility drugs and risk of ovarian cancer. Human Reproduction, 16(7), 1372-1375.

Use of fertility drugs and risk of ovarian cancer. / Parazzini, Fabio; Pelucchi, Claudio; Negri, Eva; Franceschi, Silvia; Talamini, Renato; Montella, Maurizio; La Vecchia, Carlo.

In: Human Reproduction, Vol. 16, No. 7, 2001, p. 1372-1375.

Research output: Contribution to journalArticle

Parazzini, F, Pelucchi, C, Negri, E, Franceschi, S, Talamini, R, Montella, M & La Vecchia, C 2001, 'Use of fertility drugs and risk of ovarian cancer', Human Reproduction, vol. 16, no. 7, pp. 1372-1375.
Parazzini F, Pelucchi C, Negri E, Franceschi S, Talamini R, Montella M et al. Use of fertility drugs and risk of ovarian cancer. Human Reproduction. 2001;16(7):1372-1375.
Parazzini, Fabio ; Pelucchi, Claudio ; Negri, Eva ; Franceschi, Silvia ; Talamini, Renato ; Montella, Maurizio ; La Vecchia, Carlo. / Use of fertility drugs and risk of ovarian cancer. In: Human Reproduction. 2001 ; Vol. 16, No. 7. pp. 1372-1375.
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