Use of Glubran 2 acrylic glue in interventional neuroradiology

L. Raffi, L. Simonetti, P. Cenni, M. Leonardi

Research output: Contribution to journalArticlepeer-review


Introduction: Glubran 2 is a cyanoacrylate-based synthetic glue modified by the addition of a monomer synthesized by the manufacturer. With this material it is possible to obtain the stability of endovascular embolization that is needed to treat tumours and vascular disease. Material and methods: We report our 3-year experience of the use of Glubran for treating extracerebral tumours, spinal tumours, spinal arteriovenous malformations, and brain and spine dural fistulae. Glubran 2 was diluted with Lipiodol and injected in a continuous column with the flow rate monitored by seriography. The injection was stopped when retrograde flow was displayed in the afferent vessel. Results: There were no periprocedural or subsequent clinical complications and the glue resulted in successful selective permanent occlusion with intralesional penetration similar to the angiographic features of microcatheterization. Conclusions: The embolization procedure was technically straightforward and relatively safe. However, Glubran 2 can be difficult to use and the procedure does carry major risks for patients. Glue injection requires in-depth study of the lesion, its circulation and the collateral circulation to avoid severe complications due to inappropriate use.

Original languageEnglish
Pages (from-to)829-836
Number of pages8
Issue number10
Publication statusPublished - Oct 2007


  • Arteriovenous malformation
  • Coaxial system
  • Embolization
  • Fistula
  • Glue
  • Guiding catheter
  • Tumour

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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