Use of Glubran 2 acrylic glue in interventional neuroradiology

L. Raffi, L. Simonetti, P. Cenni, M. Leonardi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Introduction: Glubran 2 is a cyanoacrylate-based synthetic glue modified by the addition of a monomer synthesized by the manufacturer. With this material it is possible to obtain the stability of endovascular embolization that is needed to treat tumours and vascular disease. Material and methods: We report our 3-year experience of the use of Glubran for treating extracerebral tumours, spinal tumours, spinal arteriovenous malformations, and brain and spine dural fistulae. Glubran 2 was diluted with Lipiodol and injected in a continuous column with the flow rate monitored by seriography. The injection was stopped when retrograde flow was displayed in the afferent vessel. Results: There were no periprocedural or subsequent clinical complications and the glue resulted in successful selective permanent occlusion with intralesional penetration similar to the angiographic features of microcatheterization. Conclusions: The embolization procedure was technically straightforward and relatively safe. However, Glubran 2 can be difficult to use and the procedure does carry major risks for patients. Glue injection requires in-depth study of the lesion, its circulation and the collateral circulation to avoid severe complications due to inappropriate use.

Original languageEnglish
Pages (from-to)829-836
Number of pages8
JournalNeuroradiology
Volume49
Issue number10
DOIs
Publication statusPublished - Oct 2007

Fingerprint

Adhesives
Cyanoacrylates
Ethiodized Oil
Neoplasms
Collateral Circulation
Injections
Arteriovenous Malformations
Vascular Diseases
Fistula
Spine
Brain
glubran 2
glubran

Keywords

  • Arteriovenous malformation
  • Coaxial system
  • Embolization
  • Fistula
  • Glue
  • Guiding catheter
  • Tumour

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Raffi, L., Simonetti, L., Cenni, P., & Leonardi, M. (2007). Use of Glubran 2 acrylic glue in interventional neuroradiology. Neuroradiology, 49(10), 829-836. https://doi.org/10.1007/s00234-007-0238-9

Use of Glubran 2 acrylic glue in interventional neuroradiology. / Raffi, L.; Simonetti, L.; Cenni, P.; Leonardi, M.

In: Neuroradiology, Vol. 49, No. 10, 10.2007, p. 829-836.

Research output: Contribution to journalArticle

Raffi, L, Simonetti, L, Cenni, P & Leonardi, M 2007, 'Use of Glubran 2 acrylic glue in interventional neuroradiology', Neuroradiology, vol. 49, no. 10, pp. 829-836. https://doi.org/10.1007/s00234-007-0238-9
Raffi, L. ; Simonetti, L. ; Cenni, P. ; Leonardi, M. / Use of Glubran 2 acrylic glue in interventional neuroradiology. In: Neuroradiology. 2007 ; Vol. 49, No. 10. pp. 829-836.
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