Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study

Augusto Di Castelnuovo, Simona Costanzo, Andrea Antinori, Nausicaa Berselli, Lorenzo Blandi, Raffaele Bruno, Roberto Cauda, Giovanni Guaraldi, Lorenzo Menicanti, Ilaria My, Giustino Parruti, Giuseppe Patti, Stefano Perlini, Francesca Santilli, Carlo Signorelli, Enrico Spinoni, Giulio G. Stefanini, Alessandra Vergori, Walter Ageno, Antonella AgodiLuca Aiello, Piergiuseppe Agostoni, Samir Al Moghazi, Marinella Astuto, Filippo Aucella, Greta Barbieri, Alessandro Bartoloni, Marialaura Bonaccio, Paolo Bonfanti, Francesco Cacciatore, Lucia Caiano, Francesco Cannata, Laura Carrozzi, Antonio Cascio, Arturo Ciccullo, Antonella Cingolani, Francesco Cipollone, Claudia Colomba, Francesca Crosta, Chiara Dal Pra, Gian Battista Danzi, Damiano D'Ardes, Katleen de Gaetano Donati, Paola Del Giacomo, Francesco Di Gennaro, Giuseppe Di Tano, Giampiero D'Offizi, Tommaso Filippini, Francesco Maria Fusco, Ivan Gentile, Alessandro Gialluisi, Giancarlo Gini, Elvira Grandone, Leonardo Grisafi, Gabriella Guarnieri, Silvia Lamonica, Francesco Landi, Armando Leone, Gloria Maccagni, Sandro Maccarella, Andrea Madaro, Massimo Mapelli, Riccardo Maragna, Lorenzo Marra, Giulio Maresca, Claudia Marotta, Franco Mastroianni, Maria Mazzitelli, Alessandro Mengozzi, Francesco Menichetti, Marianna Meschiari, Filippo Minutolo, Arturo Montineri, Roberta Mussinelli, Cristina Mussini, Maria Musso, Anna Odone, Marco Olivieri, Emanuela Pasi, Francesco Petri, Biagio Pinchera, Carlo A. Pivato, Venerino Poletti, Claudia Ravaglia, Massimo Rinaldi, Andrea Rognoni, Marco Rossato, Ilaria Rossi, Marianna Rossi, Anna Sabena, Francesco Salinaro, Vincenzo Sangiovanni, Carlo Sanrocco, Laura Scorzolini, Raffaella Sgariglia, Paola Giustina Simeone, Michele Spinicci, Enrico Maria Trecarichi, Amedeo Venezia, Giovanni Veronesi, Roberto Vettor, Andrea Vianello, Marco Vinceti, Laura Vocciante, Raffaele De Caterina, Licia Iacoviello

Research output: Contribution to journalArticlepeer-review

Abstract

Background Hydroxychloroquine (HCQ) was proposed as potential treatment for COVID-19. Objective We set-up a multicenter Italian collaboration to investigate the relationship between HCQ therapy and COVID-19 in-hospital mortality. Methods In a retrospective observational study, 3,451 unselected patients hospitalized in 33 clinical centers in Italy, from February 19, 2020 to May 23, 2020, with laboratory-confirmed SARS-CoV-2 infection, were analyzed. The primary end-point in a time-to event analysis was in-hospital death, comparing patients who received HCQ with patients who did not. We used multivariable Cox proportional-hazards regression models with inverse probability for treatment weighting by propensity scores, with the addition of subgroup analyses. Results Out of 3,451 COVID-19 patients, 76.3% received HCQ. Death rates (per 1,000 person-days) for patients receiving or not HCQ were 8.9 and 15.7, respectively. After adjustment for propensity scores, we found 30% lower risk of death in patients receiving HCQ (HR=0.70; 95%CI: 0.59 to 0.84; E-value=1.67). Secondary analyses yielded similar results. The inverse association of HCQ with inpatient mortality was particularly evident in patients having elevated C-reactive protein at entry. Conclusions HCQ use was associated with a 30% lower risk of death in COVID-19 hospitalized patients. Within the limits of an observational study and awaiting results from randomized controlled trials, these data do not discourage the use of HCQ in inpatients with COVID-19.
Original languageEnglish
Pages (from-to)38-47
Number of pages10
JournalEur. J. Intern. Med.
Volume82
DOIs
Publication statusPublished - 2020

Keywords

  • Hydroxychloroquine
  • COVID-19
  • Disease severity
  • Mortality
  • Inflammation

Fingerprint

Dive into the research topics of 'Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study'. Together they form a unique fingerprint.

Cite this