Use of inhaled nitric oxide in the treatment of right ventricular myocardial infarction

Valentina Valenti, Amisha J. Patel, Sebastiano Sciarretta, Hassan Kandil, Fabrizio Bettini, Andrea Ballotta

Research output: Contribution to journalArticle

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Abstract

In 50% of acute left ventricular inferior-posterior wall myocardial infarction (MI), concomitant right ventricular MI (RVMI) has been reported, with a dramatic increased rate of mortality. We report the case of a woman with RVMI complicated by cardiogenic shock due to dissection of the right coronary artery. She was treated with liquid infusion, epinephrine, milrinone, and an intraaortic balloon pump, but clinical condition decreased. She was then intubated, and prolonged inhalation of nitric oxide (12-15 ppm) was added. Both clinical and hemodynamic parameters slowly improved with decrease of systemic (2513 ± 708 shifted to 1802 ± 369 dynes × s/cm5) and pulmonary vascular resistance (365 ± 183 to 309 ± 80 dynes × s/cm5) and central venous pressure (fell from 13 ± 4 mm Hg to 6 ± 4 mm Hg) and improvement of cardiac index (from 2.2 ± 0.5 to 3 ±0.3 L/min per square meter). Inhalation of nitric oxide (iNO) withdrawal on day 7 caused a significant rebound pulmonary hypertension with decrease of cardiac output. Inhalation of nitric oxide was then reinstituted until day 8 and was finally gradually withdrawn without major hemodynamic variations. The patient was weaned from the ventilator on day 9 and was stable clinically and hemodynamically.

Original languageEnglish
JournalAmerican Journal of Emergency Medicine
Volume29
Issue number4
DOIs
Publication statusPublished - May 2011

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Inhalation
Nitric Oxide
Myocardial Infarction
Hemodynamics
Milrinone
Inferior Wall Myocardial Infarction
Women's Rights
Central Venous Pressure
Cardiogenic Shock
Mechanical Ventilators
Pulmonary Hypertension
Cardiac Output
Vascular Resistance
Epinephrine
Dissection
Coronary Vessels
Therapeutics
Mortality

ASJC Scopus subject areas

  • Emergency Medicine

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Use of inhaled nitric oxide in the treatment of right ventricular myocardial infarction. / Valenti, Valentina; Patel, Amisha J.; Sciarretta, Sebastiano; Kandil, Hassan; Bettini, Fabrizio; Ballotta, Andrea.

In: American Journal of Emergency Medicine, Vol. 29, No. 4, 05.2011.

Research output: Contribution to journalArticle

Valenti, Valentina ; Patel, Amisha J. ; Sciarretta, Sebastiano ; Kandil, Hassan ; Bettini, Fabrizio ; Ballotta, Andrea. / Use of inhaled nitric oxide in the treatment of right ventricular myocardial infarction. In: American Journal of Emergency Medicine. 2011 ; Vol. 29, No. 4.
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