Use of intercross outbred mice and single nucleotide polymorphisms to map skin cancer modifier loci

Bernard Peissel, Daniela Zaffaroni, Simonetta Pazzaglia, Giacomo Manenti, Nicola Zanesi, Ignazio Zedda, Simonetta Rebessi, Vincenzo Covelli, Tommaso A. Dragani, Anna Saran

Research output: Contribution to journalArticle

Abstract

Car-R and Car-S outbred mouse lines, phenotypically selected for resistance and susceptibility to skin carcinogenesis respectively, show significant linkage disequilibrium (LD) at genetic markers mapping on chromosomal regions where skin cancer modifier loci (Skts3, Skts1, and Psl1 on Chrs 5, 7, and 9 respectively) have been mapped in standard crosses. Analysis of these regions for genetic linkage with skin cancer phehotypes in 245 (Car-R × Car-S)F2 intercross mice, by using single nucleotide polymorphisms (SNPs), revealed significant linkage at a possible allelic form of the Skts1 locus, whose mapping region was shortened to a

Original languageEnglish
Pages (from-to)291-294
Number of pages4
JournalMammalian Genome
Volume12
Issue number4
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Genetics

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