Use of IVUS guided coronary stenting with drug eluting stent: A systematic review and meta-analysis of randomized controlled clinical trials and high quality observational studies

Catherine Klersy, Marco Ferlini, Arturo Raisaro, Valeria Scotti, Anna Balduini, Moreno Curti, Ezio Bramucci, Annalisa De Silvestri

Research output: Contribution to journalArticle


Background/objectives Long term safety of DES, particularly regarding thrombosis is of concern. The hypothesized underlying mechanisms (stent underexpansion, malapposition) could be prevented by IVUS guidance. Aim of this meta-analysis of randomized controlled clinical trials (RCT) and high quality observational cohort studies (HQ-OBS) is to quantify the potential clinical benefit of intravascular ultrasound (IVUS) guidance in drug-eluting stents (DES) implantation. Methods We performed an extensive literature search for full-text articles published in 2003-2013. The primary outcome was the rate of major adverse cardiac events (MACE) in RCT and HQ-OBS; secondary outcomes were death, myocardial infarction (MI), revascularization, thrombosis and post-procedural minimum lumen diameter (MLD). Fixed/random effect relative risks (RRs) or standardized mean difference (SMD) and 95% confidence interval (95% CI) were computed for the meta-analysis. Results Thirty-four articles were retrieved from 268 found; of these 3 were RCT and 9 were HQ-OBS; 18,707 patients were enrolled, 1037 in RCT and 17,670 in OBS. Median follow-up was 20 months. IVUS guidance was associated with a significantly lower rate of MACE (RR = 0.80, 95% CI 0.71-0.89, p <0.001), death (RR = 0.60, 95% CI 0.48-0.74, p <0.001), MI (RR = 0.59, 95% CI 0.44-0.80, p = 0.001) and thrombosis (RR = 0.50, 95% CI 0.32-0.80, p = 0.007) and larger MLD (SMD = 0.15, 95% CI 0.03 to 0.27, p = 0.014), but not of revascularization (RR = 0.95, 95% CI 0.82-1.09, p = 0.75). Conclusions In this meta-analysis, IVUS guidance in DES implantation appears to reduce MACE, mortality and MI, possibly by reducing thrombosis rather than restenosis rate. Patients at high risk for thrombosis might be identified as the best candidate for IVUS guidance.

Original languageEnglish
Pages (from-to)54-63
Number of pages10
JournalInternational Journal of Cardiology
Issue number1
Publication statusPublished - Dec 5 2013



  • Drug eluting stent
  • High quality observational studies
  • Intravascular ultrasound
  • MACE
  • Meta-analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this