Use of linezolid in infants and children: A retrospective multicentre study of the Italian society for paediatric infectious diseases

Silvia Garazzino, Andrzej Krzysztofiak, Susanna Esposito, Elio Castagnola, Alessandro Plebani, Luisa Galli, Monica Cellini, Rita Lipreri, Carlo Scolfaro, Chiara Bertaina, Carmelina Calitri, Elena Bozzola, Laura Lancella, Anna Quondamcarlo, Samantha Bosis, Lorenza Pugni, Giuseppe Losurdo, Annarosa Soresina, Marina De Gaudio, Ilaria MariottiLuca Mancini, Clara Gabiano, Pier Angelo Tovo

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Because of the spread of drug-resistant Gram-positive bacteria, the use of linezolid for treating severe infections is increasing. However, clinical experience in the paediatric population is still limited. We undertook a multicentre study to analyse the use of linezolid in children. Methods: Hospitalized children treated with linezolid for a suspected or proven Gram-positive or mycobacterial infection were analysed retrospectively. Side effects were investigated, focusing on younger children and longterm treatments. Results: Seventy-five patients (mean age 6.8 years, range 7 days to 17 years) were studied. Mean±SD linezolid treatment duration was 26.13±17 days. Clinical cure was achieved in 74.7% of patients. The most frequent adverse events were diarrhoea and vomiting. Two patients had severe anaemia, two neutropenia and one thrombocytopenia. Two cases of grade 3 liver function test elevation and one case of pancreatitis were reported. The overall frequency of adverse events was similar between patients treated for >28 days and those receiving shorter treatments (30.8% versus 28.6%, P=0.84). Children aged,

Original languageEnglish
Article numberdkr285
Pages (from-to)2393-2397
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume66
Issue number10
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Anaemia
  • Oxazolidinones
  • Paediatrics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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